8gsc: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8gsc is ON HOLD  until sometime in the future
+==Echovirus3 A-particle in complex with 6D10 Fab==
+<StructureSection load='8gsc' size='340' side='right'caption='[[8gsc]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8gsc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E3 Echovirus E3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GSC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gsc OCA], [https://pdbe.org/8gsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gsc RCSB], [https://www.ebi.ac.uk/pdbsum/8gsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gsc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A060BKX4_9ENTO A0A060BKX4_9ENTO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs.
-Authors: Wang, X., Fu, W.
+Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.,Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420<ref>PMID:36366420</ref>
-Description: Echovirus3 A-particle in complex with 6D10 fab
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Fu, W]]
+<div class="pdbe-citations 8gsc" style="background-color:#fffaf0;"></div>
-[[Category: Wang, X]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Echovirus E3]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Fu W]]
+[[Category: Wang X]]