8e76: Difference between revisions

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'''Unreleased structure'''


The entry 8e76 is ON HOLD  until 2024-08-23
==Cryo-EM structure of Apo form ME3==
<StructureSection load='8e76' size='340' side='right'caption='[[8e76]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8e76]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E76 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e76 OCA], [https://pdbe.org/8e76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e76 RCSB], [https://www.ebi.ac.uk/pdbsum/8e76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e76 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAON_HUMAN MAON_HUMAN] Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469).<ref>PMID:7818469</ref>


Authors: Yu, X., Grell, T.A.J., Shaffer, P.L., Steele, R., Sharma, S., Thompson, A.A., Tresadern, G., Ortiz-Meoz, R.F., Mason, M., Gomez-Tamayo, J.C., Riley, D., Wagner, M.V., Wadia, J.
==See Also==
 
*[[NADP-dependent malic enzyme|NADP-dependent malic enzyme]]
Description: Cryo-EM structure of Apo form ME3
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Yu, X]]
__TOC__
[[Category: Tresadern, G]]
</StructureSection>
[[Category: Thompson, A.A]]
[[Category: Homo sapiens]]
[[Category: Mason, M]]
[[Category: Large Structures]]
[[Category: Grell, T.A.J]]
[[Category: Gomez-Tamayo JC]]
[[Category: Gomez-Tamayo, J.C]]
[[Category: Grell TAJ]]
[[Category: Wadia, J]]
[[Category: Mason M]]
[[Category: Sharma, S]]
[[Category: Ortiz-Meoz RF]]
[[Category: Riley, D]]
[[Category: Riley D]]
[[Category: Steele, R]]
[[Category: Shaffer PL]]
[[Category: Wagner, M.V]]
[[Category: Sharma S]]
[[Category: Ortiz-Meoz, R.F]]
[[Category: Steele R]]
[[Category: Shaffer, P.L]]
[[Category: Thompson AA]]
[[Category: Tresadern G]]
[[Category: Wadia J]]
[[Category: Wagner MV]]
[[Category: Yu X]]

Latest revision as of 09:33, 19 June 2024

Cryo-EM structure of Apo form ME3Cryo-EM structure of Apo form ME3

Structural highlights

8e76 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.51Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MAON_HUMAN Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469).[1]

See Also

References

  1. Loeber G, Maurer-Fogy I, Schwendenwein R. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):687-92. PMID:7818469 doi:10.1042/bj3040687

8e76, resolution 2.51Å

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OCA