8ar2: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8ar2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[8ar2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar2 OCA], [https://pdbe.org/8ar2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar2 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar2 OCA], [https://pdbe.org/8ar2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TLR5_HUMAN TLR5_HUMAN] Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:11323673</ref> | [https://www.uniprot.org/uniprot/TLR5_HUMAN TLR5_HUMAN] Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:11323673</ref> | ||
==See Also== | |||
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 09:25, 19 June 2024
Solution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regionsSolution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regions
Structural highlights
DiseaseTLR5_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. FunctionTLR5_HUMAN Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1] See AlsoReferences
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