8abq: Difference between revisions

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'''Unreleased structure'''


The entry 8abq is ON HOLD  until Paper Publication
==Structure of the SNX1-SNX5 complex, Pt derivative==
<StructureSection load='8abq' size='340' side='right'caption='[[8abq]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8abq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ABQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ABQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8abq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8abq OCA], [https://pdbe.org/8abq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8abq RCSB], [https://www.ebi.ac.uk/pdbsum/8abq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8abq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref>


Authors:  
==See Also==
 
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Astorga-Simon EN]]
[[Category: Banos-Mateos S]]
[[Category: Castano D]]
[[Category: Hierro A]]
[[Category: Lopez-Robles C]]
[[Category: Rojas AL]]
[[Category: Scaramuzza S]]
[[Category: Vidaurrazaga A]]

Latest revision as of 09:24, 19 June 2024

Structure of the SNX1-SNX5 complex, Pt derivativeStructure of the SNX1-SNX5 complex, Pt derivative

Structural highlights

8abq is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.81Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNX1_HUMAN May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).[1] [2] [3]

See Also

References

  1. ↑ Cozier GE, Carlton J, McGregor AH, Gleeson PA, Teasdale RD, Mellor H, Cullen PJ. The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002 Dec 13;277(50):48730-6. Epub 2002 Aug 26. PMID:12198132 doi:10.1074/jbc.M206986200
  2. ↑ Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT, Cullen PJ. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol. 2004 Oct 26;14(20):1791-800. PMID:15498486 doi:10.1016/j.cub.2004.09.077
  3. ↑ Rojas R, Kametaka S, Haft CR, Bonifacino JS. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007 Feb;27(3):1112-24. Epub 2006 Nov 13. PMID:17101778 doi:10.1128/MCB.00156-06

8abq, resolution 2.81Å

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