7zk2: Difference between revisions

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-'''Unreleased structure'''
-The entry 7zk2 is ON HOLD
+==Crystal Structure of human Brachyury G177D variant in complex with CSC027898502==
+<StructureSection load='7zk2' size='340' side='right'caption='[[7zk2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Newman, J.A., Gavard, A., Aitkenhead, H., Imprachim, N., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Bountra, C., Gileadi, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZK2 FirstGlance]. <br>
-Description: Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IU4:N-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]ethanamide'>IU4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Burgess-Brown, N.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zk2 OCA], [https://pdbe.org/7zk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7zk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zk2 ProSAT]</span></td></tr>
-[[Category: Von Delft, F]]
+</table>
-[[Category: Aitkenhead, H]]
+== Disease ==
-[[Category: Sherestha, L]]
+[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.  The disease is caused by mutations affecting the gene represented in this entry.
-[[Category: Gileadi, O]]
+== Function ==
-[[Category: Newman, J.A]]
+[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
-[[Category: Imprachim, N]]
+__TOC__
-[[Category: Gavard, A]]
+</StructureSection>
-[[Category: Bountra, C]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Aitkenhead H]]
+[[Category: Bountra C]]
+[[Category: Burgess-Brown NA]]
+[[Category: Gavard A]]
+[[Category: Gileadi O]]
+[[Category: Imprachim N]]
+[[Category: Newman JA]]
+[[Category: Sherestha L]]
+[[Category: Von Delft F]]