7zb5: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7zb5]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum] and [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZB5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7zb5]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum] and [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZB5 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zb5 OCA], [https://pdbe.org/7zb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7zb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zb5 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zb5 OCA], [https://pdbe.org/7zb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7zb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zb5 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/G0SAL6_CHATD G0SAL6_CHATD] | [https://www.uniprot.org/uniprot/G0SAL6_CHATD G0SAL6_CHATD] | ||
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== Publication Abstract from PubMed == | |||
The Swi2/Snf2 family transcription regulator Modifier of Transcription 1 (Mot1) uses adenosine triphosphate (ATP) to dissociate and reallocate the TATA box-binding protein (TBP) from and between promoters. To reveal how Mot1 removes TBP from TATA box DNA, we determined cryogenic electron microscopy structures that capture different states of the remodeling reaction. The resulting molecular video reveals how Mot1 dissociates TBP in a process that, intriguingly, does not require DNA groove tracking. Instead, the motor grips DNA in the presence of ATP and swings back after ATP hydrolysis, moving TBP to a thermodynamically less stable position on DNA. Dislodged TBP is trapped by a chaperone element that blocks TBP's DNA binding site. Our results show how Swi2/Snf2 proteins can remodel protein-DNA complexes through DNA bending without processive DNA tracking and reveal mechanistic similarities to RNA gripping DEAD box helicases and RIG-I-like immune sensors. | |||
Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.,Woike S, Eustermann S, Jung J, Wenzl SJ, Hagemann G, Bartho J, Lammens K, Butryn A, Herzog F, Hopfner KP Nat Struct Mol Biol. 2023 May;30(5):640-649. doi: 10.1038/s41594-023-00966-0. , Epub 2023 Apr 27. PMID:37106137<ref>PMID:37106137</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 7zb5" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||