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The | ==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo== | ||
<StructureSection load='7trk' size='340' side='right'caption='[[7trk]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7trk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trk OCA], [https://pdbe.org/7trk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trk RCSB], [https://www.ebi.ac.uk/pdbsum/7trk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. | |||
==See Also== | |||
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Belousoff MJ]] | |||
[[Category: Danev R]] | |||
[[Category: Glukhova A]] | |||
[[Category: Mobbs JI]] | |||
[[Category: Sexton PM]] | |||
[[Category: Thal DM]] | |||
[[Category: Vuckovic Z]] | |||
Latest revision as of 14:34, 23 October 2024
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxoHuman M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo
Structural highlights
FunctionACM4_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. See Also |
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