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==== | ==SARS-CoV-2 Omicron Variant S Trimer complexed with one JMB2002 Fab== | ||
<StructureSection load='7wpd' size='340' side='right'caption='[[7wpd]]' scene=''> | <StructureSection load='7wpd' size='340' side='right'caption='[[7wpd]], [[Resolution|resolution]] 3.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wpd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WPD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wpd OCA], [https://pdbe.org/7wpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wpd RCSB], [https://www.ebi.ac.uk/pdbsum/7wpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wpd ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wpd OCA], [https://pdbe.org/7wpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wpd RCSB], [https://www.ebi.ac.uk/pdbsum/7wpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wpd ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron mutations are located on the surface of the spike protein and change binding epitopes to many current antibodies. In the ACE2-binding site, compensating mutations strengthen receptor binding domain (RBD) binding to ACE2. Both the RBD and the apo form of the Omicron spike trimer are thermodynamically unstable. An unusual RBD-RBD interaction in the ACE2-spike complex supports the open conformation and further reinforces ACE2 binding to the spike trimer. A broad-spectrum therapeutic antibody, JMB2002, which has completed a phase 1 clinical trial, maintains neutralizing activity against Omicron. JMB2002 binds to RBD differently from other characterized antibodies and inhibits ACE2 binding. | |||
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.,Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE Science. 2022 Mar 4;375(6584):1048-1053. doi: 10.1126/science.abn8863. Epub 2022 , Feb 8. PMID:35133176<ref>PMID:35133176</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7wpd" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z | [[Category: Mus musculus]] | ||
[[Category: Severe acute respiratory syndrome coronavirus 2]] | |||
[[Category: Cao X]] | |||
[[Category: Cheng X]] | |||
[[Category: Deng SJ]] | |||
[[Category: Gu C]] | |||
[[Category: He X]] | |||
[[Category: Hu W]] | |||
[[Category: Huang S]] | |||
[[Category: Huang Z]] | |||
[[Category: Jia F]] | |||
[[Category: Jiang H]] | |||
[[Category: Jiang Y]] | |||
[[Category: Liu J]] | |||
[[Category: Liu P]] | |||
[[Category: Song B]] | |||
[[Category: Wang X]] | |||
[[Category: Wang Z]] | |||
[[Category: Wu C]] | |||
[[Category: Wu K]] | |||
[[Category: Xia K]] | |||
[[Category: Xu HE]] | |||
[[Category: Xu P]] | |||
[[Category: Xu Y]] | |||
[[Category: Yin W]] | |||
[[Category: Yuan Q]] | |||
[[Category: Zheng J]] | |||