7qfp: Difference between revisions

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<StructureSection load='7qfp' size='340' side='right'caption='[[7qfp]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='7qfp' size='340' side='right'caption='[[7qfp]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7qfp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFP FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfp OCA], [https://pdbe.org/7qfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfp RCSB], [https://www.ebi.ac.uk/pdbsum/7qfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfp ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfp OCA], [https://pdbe.org/7qfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfp RCSB], [https://www.ebi.ac.uk/pdbsum/7qfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfp ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Botulinum neurotoxins (BoNTs) are the causative agents of a potentially lethal paralytic disease targeting cholinergic nerve terminals. Multiple BoNT serotypes exist, with types A, B and E being the main cause of human botulism. Their extreme toxicity has been exploited for cosmetic and therapeutic uses to treat a wide range of neuromuscular disorders. Although naturally occurring BoNT types share a common end effect, their activity varies significantly based on the neuronal cell-surface receptors and intracellular SNARE substrates they target. These properties are the result of structural variations that have traditionally been studied using biophysical methods such as X-ray crystallography. Here, we determined the first structures of botulinum neurotoxins using single-particle cryogenic electron microscopy. The maps obtained at 3.6 and 3.7 A for BoNT/B and /E, respectively, highlight the subtle structural dynamism between domains, and of the binding domain in particular. This study demonstrates how the recent advances made in the field of single-particle electron microscopy can be applied to bacterial toxins of clinical relevance and the botulinum neurotoxin family in particular.


Structural Analysis of Botulinum Neurotoxins Type B and E by Cryo-EM.,Kosenina S, Martinez-Carranza M, Davies JR, Masuyer G, Stenmark P Toxins (Basel). 2021 Dec 23;14(1). pii: toxins14010014. doi:, 10.3390/toxins14010014. PMID:35050991<ref>PMID:35050991</ref>
==See Also==
 
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7qfp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Davies, J R]]
[[Category: Davies JR]]
[[Category: Kosenina, S]]
[[Category: Kosenina S]]
[[Category: Martinez-Carranza, M]]
[[Category: Martinez-Carranza M]]
[[Category: Masuyer, G]]
[[Category: Masuyer G]]
[[Category: Stenmark, P]]
[[Category: Stenmark P]]
[[Category: Clostridium botulinum]]
[[Category: Neurotoxin]]
[[Category: Toxin]]

Latest revision as of 16:55, 6 November 2024

Cryo-EM structure of Botulinum neurotoxin serotype ECryo-EM structure of Botulinum neurotoxin serotype E

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

7qfp, resolution 3.70Å

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