Arsenite resistance protein: Difference between revisions
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'''Arsenite Resistance Protein''' (ARS2), otherwise known as the '''Serrate RNA effector molecule homolog''', is a protein that is found in many species. The ARS2 being observed today, however, is from humans. It is produced by the SRRT gene [5]. ARS2 was originally discovered because of its ability to provide arsenic resistance in organisms. The first of its kind was found in plants (such as Arabidopsis thaliana), but since has been discovered in Drosophila and, in this case, humans. In Drosophila and other metazoans, ARS2 was found to have another purpose besides arsenic resistance. It was also found to help with RNA [4]. It can be used, in conjunction with other proteins (such as the cap-binding complex, CBC) to form a multiprotein complex. ARS2 serves as the mediator between this complex and micro-RNA (miRNA), which binds to DNA to silence gene expression [5]. Interestingly, ARS2 is also used in RNA production and RNA decay. CBC binds to ARS2, which helps ARS2 bind to other RNA enzymes and the RNA itself. ARS2 is a scaffold protein in that it brings multiple functional proteins together with RNA to achieve an effect. It also helps in proliferation and mammalian development due to this RNA metabolism. ARS2 can conjoin with multiple proteins and has a multifunctional purpose [3]. | '''Arsenite Resistance Protein''' (ARS2), otherwise known as the '''Serrate RNA effector molecule homolog''', is a protein that is found in many species. The ARS2 being observed today, however, is from humans. It is produced by the SRRT gene [5]. ARS2 was originally discovered because of its ability to provide arsenic resistance in organisms. The first of its kind was found in plants (such as Arabidopsis thaliana), but since has been discovered in Drosophila and, in this case, humans. In Drosophila and other metazoans, ARS2 was found to have another purpose besides arsenic resistance. It was also found to help with RNA [4]. It can be used, in conjunction with other proteins (such as the cap-binding complex, CBC) to form a multiprotein complex. ARS2 serves as the mediator between this complex and micro-RNA (miRNA), which binds to DNA to silence gene expression [5]. Interestingly, ARS2 is also used in RNA production and RNA decay. CBC binds to ARS2, which helps ARS2 bind to other RNA enzymes and the RNA itself. ARS2 is a scaffold protein in that it brings multiple functional proteins together with RNA to achieve an effect. It also helps in proliferation and mammalian development due to this RNA metabolism. ARS2 can conjoin with multiple proteins and has a multifunctional purpose [3]. | ||
<Structure load='6F7J' size='350' frame='true' align='right' caption='Arsenite resistance protein residues 171-270 (grey) and 408-763 (green) (PDB code [[6f7j]]) | <Structure load='6F7J' size='350' frame='true' align='right' caption='Arsenite resistance protein residues 171-270 (grey) and 408-763 (green) (PDB code [[6f7j]])' scene='Insert optional scene name here' /> | ||
== Structural highlights == | == Structural highlights == | ||
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'''Image 2.''' The structure of ARG2. N-terminus is in upper right (orange) [2]. | '''Image 2.''' The structure of ARG2. N-terminus is in upper right (orange) [2]. | ||
==3D structures of arsenite resistance protein== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[6f7p]], [[6f7s]] – hARS2 residues 147-270+408-763 – human<br /> | |||
[[6f7j]], [[6f8d]] – hARS2 residues 171-270+408-763 <br /> | |||
[[8pmp]] - hARS2 residues 148-867 + nuclear cap-binding protein – Cryo EM<br /> | |||
== References == | == References == | ||
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5.SRRT - Serrate RNA effector molecule homolog - Homo sapiens (Human) - SRRT gene & protein. (n.d.). Www.uniprot.org. Retrieved October 14, 2021, from https://www.uniprot.org/uniprot/Q9BXP5#interaction | 5.SRRT - Serrate RNA effector molecule homolog - Homo sapiens (Human) - SRRT gene & protein. (n.d.). Www.uniprot.org. Retrieved October 14, 2021, from https://www.uniprot.org/uniprot/Q9BXP5#interaction | ||
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