7ruh: Difference between revisions
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New page: '''Unreleased structure''' The entry 7ruh is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844== | |||
<StructureSection load='7ruh' size='340' side='right'caption='[[7ruh]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ruh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QZ:1-[5-[1-(1,1-dipyridin-2-ylethyl)-4-[2,2,2-tris(fluoranyl)ethylsulfonylamino]indol-6-yl]-1-methyl-2-oxidanylidene-pyridin-3-yl]-3-(2-fluorophenyl)urea'>7QZ</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ruh OCA], [https://pdbe.org/7ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ruh RCSB], [https://www.ebi.ac.uk/pdbsum/7ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ruh ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dubrovyskyii O]] | |||
[[Category: Huang F]] | |||
[[Category: Li Y]] | |||
[[Category: Ratia KM]] | |||
[[Category: Shen Z]] | |||
[[Category: Thatcher GR]] | |||
[[Category: Xiong R]] | |||
[[Category: Zhao J]] | |||
Latest revision as of 16:59, 6 November 2024
Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). See AlsoReferences
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