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==ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs==
==ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs==
<StructureSection load='7bmk' size='340' side='right'caption='[[7bmk]]' scene=''>
<StructureSection load='7bmk' size='340' side='right'caption='[[7bmk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BMK FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BMK FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bmk OCA], [https://pdbe.org/7bmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bmk RCSB], [https://www.ebi.ac.uk/pdbsum/7bmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bmk ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=U4N:2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide'>U4N</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bmk OCA], [https://pdbe.org/7bmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bmk RCSB], [https://www.ebi.ac.uk/pdbsum/7bmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bmk ProSAT]</span></td></tr>
</table>
</table>
==See Also==
*[[Ire1|Ire1]]
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__TOC__
</StructureSection>
</StructureSection>

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