7b47: Difference between revisions
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New page: '''Unreleased structure''' The entry 7b47 is ON HOLD Authors: Degtjarik, O., Rozenberg, H., Shakked, Z. Description: p53 structure 1 Category: Unreleased Structures [[Category: Roz... |
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==Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I)== | |||
<StructureSection load='7b47' size='340' side='right'caption='[[7b47]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B47 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QN8:(2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one'>QN8</scene>, <scene name='pdbligand=QNN:(2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one'>QNN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b47 OCA], [https://pdbe.org/7b47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b47 RCSB], [https://www.ebi.ac.uk/pdbsum/7b47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b47 ProSAT]</span></td></tr> | |||
</table> | |||
==See Also== | |||
*[[P53 3D structures|P53 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Degtjarik O]] | ||
[[Category: | [[Category: Rozenberg H]] | ||
[[Category: Shakked Z]] | |||
Latest revision as of 13:52, 23 October 2024
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I)Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I)
Structural highlights
See Also |
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