7ks3: Difference between revisions

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-'''Unreleased structure'''
-The entry 7ks3 is ON HOLD  until Paper Publication
+==GluK2/K5 with L-Glu==
+<StructureSection load='7ks3' size='340' side='right'caption='[[7ks3]], [[Resolution|resolution]] 5.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ks3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KS3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ks3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ks3 OCA], [https://pdbe.org/7ks3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ks3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ks3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ks3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GRIK5_RAT GRIK5_RAT] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic transmission and modulate neuronal circuits. KARs have strict assembly rules and primarily function as heteromeric receptors in the brain. A longstanding question is how KAR heteromer subunits organize and coordinate together to fulfill their signature physiological roles. Here we report structures of the GluK2/GluK5 heteromer in apo, antagonist-bound, and desensitized states. The receptor assembles with two copies of each subunit, ligand binding domains arranged as two heterodimers and GluK5 subunits proximal to the channel. Strikingly, during desensitization, GluK2, but not GluK5, subunits undergo major structural rearrangements to facilitate channel closure. We show how the large conformational differences between antagonist-bound and desensitized states are mediated by the linkers connecting the pore helices to the ligand binding domains. This work presents the first KAR heteromer structure, reveals how its subunits are organized, and resolves how the heteromer can accommodate functionally distinct closed channel structures.
-Authors:
+Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor.,Khanra N, Brown PM, Perozzo AM, Bowie D, Meyerson JR Elife. 2021 Mar 16;10:e66097. doi: 10.7554/eLife.66097. PMID:33724189<ref>PMID:33724189</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 7ks3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
+*[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aequorea victoria]]
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Bowie D]]
+[[Category: Brown PMGE]]
+[[Category: Khanra N]]
+[[Category: Meyerson JR]]
+[[Category: Perozzo AM]]