7dge: Difference between revisions

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-'''Unreleased structure'''
-The entry 7dge is ON HOLD  until Paper Publication
+==intermediate state of class C GPCR==
+<StructureSection load='7dge' size='340' side='right'caption='[[7dge]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7dge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DGE FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dge OCA], [https://pdbe.org/7dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dge RCSB], [https://www.ebi.ac.uk/pdbsum/7dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dge ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.<ref>PMID:7476890</ref>
-Authors:
+==See Also==
+*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Lama glama]]
+[[Category: Large Structures]]
+[[Category: Hua T]]
+[[Category: Liu ZJ]]
+[[Category: Luo F]]
+[[Category: Wu LJ]]
+[[Category: Zhang JY]]