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==PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione== | ==PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione== | ||
<StructureSection load='6zad' size='340' side='right'caption='[[6zad]]' scene=''> | <StructureSection load='6zad' size='340' side='right'caption='[[6zad]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZAD OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZAD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QDW:methoxymethyloxathiatetraazatetracyclodocosahexaenedione'>QDW</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zad OCA], [https://pdbe.org/6zad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zad RCSB], [https://www.ebi.ac.uk/pdbsum/6zad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zad ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase delta inhibitors, resulting in compounds with improved potency, permeability, and in vivo clearance while maintaining good solubility. The thermodynamics of binding was explored via surface plasmon resonance, and the binding of lead macrocycle 19 was found to be almost exclusively entropically driven compared with progenitor 18, which demonstrated both enthalpic and entropic contributions. The pharmacokinetics of macrocycle 19 was also explored in vivo, where it showed reduced clearance when compared with the progenitor 18. This work adds to the growing body of evidence that macrocyclization could provide an alternative and complementary approach to the design of small-molecule inhibitors, with the potential to deliver differentiated properties. | |||
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta.,Spencer JA, Baldwin IR, Barton N, Chung CW, Convery MA, Edwards CD, Jamieson C, Mallett DN, Rowedder JE, Rowland P, Thomas DA, Hardy CJ ACS Med Chem Lett. 2020 Jun 3;11(7):1386-1391. doi:, 10.1021/acsmedchemlett.0c00061. eCollection 2020 Jul 9. PMID:32676144<ref>PMID:32676144</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6zad" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 09:10, 19 June 2024
PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedionePI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione
Structural highlights
Publication Abstract from PubMedA macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase delta inhibitors, resulting in compounds with improved potency, permeability, and in vivo clearance while maintaining good solubility. The thermodynamics of binding was explored via surface plasmon resonance, and the binding of lead macrocycle 19 was found to be almost exclusively entropically driven compared with progenitor 18, which demonstrated both enthalpic and entropic contributions. The pharmacokinetics of macrocycle 19 was also explored in vivo, where it showed reduced clearance when compared with the progenitor 18. This work adds to the growing body of evidence that macrocyclization could provide an alternative and complementary approach to the design of small-molecule inhibitors, with the potential to deliver differentiated properties. Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta.,Spencer JA, Baldwin IR, Barton N, Chung CW, Convery MA, Edwards CD, Jamieson C, Mallett DN, Rowedder JE, Rowland P, Thomas DA, Hardy CJ ACS Med Chem Lett. 2020 Jun 3;11(7):1386-1391. doi:, 10.1021/acsmedchemlett.0c00061. eCollection 2020 Jul 9. PMID:32676144[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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