Nucleoside triphosphatase: Difference between revisions

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'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form.  NTPase is found in mammals and in pathogenic microbes.  In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides.  The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form.  NTPase is found in mammals and in pathogenic microbes.  In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides.  The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
*'''Nucleoside triphosphatase Nudi''' catalyses the hydrolysis of preferentially dUTP, dTTP and dCTP.


== Relevance ==
== Relevance ==
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==3D structures of nucleoside triphosphatase==
==3D structures of nucleoside triphosphatase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Nucleoside triphosphatase 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|


*Nucleoside triphosphatase 1


**[[4a57]] - TgNTPase 1 - ''Toxoplasma gondii'' <br />
**[[4a59]] - TgNTPase 1 + AMP<br />
*Nucleoside triphosphatase 2
**[[4jep]] - TgNTPase 2 <br />
**[[4a5b]] - TgNTPase 2 (mutant)<br />
**[[4kh4]], [[4a5a]] - TgNTPase 2 (mutant) + AMPPNP<br />
**[[4kh5]], [[4kh6]] - TgNTPase 2 (mutant) + AMPNP<br />
*Nucleoside triphosphatase Nudi
**[[6dt3]] - Nudi - ''Klebsiella pneumoniae'' <br />
**[[3oga]], [[3n77]] - Nudi - ''Salmonella enterica'' <br />
*Nucleoside triphosphatase cancer-related
**[[2i3b]] - NTPase - human- NMR <br />
*Nucleoside triphosphatase
**[[3s86]] - NTPase - ''Thermotoga maritima'' <br />
**[[3agr]] - NTPase - ''Neospora caninum'' <br />
**[[7aoh]] - NTPase I in transcribing complex - Vaccinia virus – Cryo EM <br />
}}
== References ==
== References ==
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[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky