Intersectin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''Intersectin''' (ITSN) is an endocytic multidomain scaffold protein in neurons and is important regulator of synaptic vescicles replenishment at hippocampal synapses.  The replenishment is needed in order to sustain neurotransmission during periods of elevated activity. ITSN interacts with synapsin I through its SH3 domains<ref>PMID:29229830</ref>. Alternative splicing of ITSN generates a short isoform with 2 EH (Eps15 homology) domains and 5 SH3 domains and a long isoform with additional DH, PH and C2 domains<ref>PMID:19037327</ref>,<ref>PMID:10922467</ref>.
+'''Intersectin''' (ITSN) is an endocytic multidomain scaffold protein in neurons and is important regulator of synaptic vescicles replenishment at hippocampal synapses.  The replenishment is needed in order to sustain neurotransmission during periods of elevated activity. ITSN interacts with synapsin I through its SH3 domains<ref>PMID:29229830</ref>.
 '''ITSN 2''' is also involved in clathrin-mediated endocytosis and is very similar to '''ITSN 1'''.
+ITSN-1 has two isoforms as a result of differential splicing:
+*'''ITSN-1 short form''' is 140kD and expressed in all tissues
+*'''ITSN-1 long form''' is 200kD and expressed in neutrons, eye, heart, blood cells and kidney<ref>PMID:32161523</ref>.
+*'''ITSN-2 short form''' contains 2 EH domains, a coiled-coil domain and 5 SH3 domains
+*'''ITSN-2 long form'''contains an extra carboxylate domain<ref>PMID:10922467</ref>.
 == Relevance ==