CTLA-4: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 5: | Line 5: | ||
'''CTLA4''' or '''Cytotoxic T-Lymphocyte Associated protein 4''' or '''CD152''' is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells<ref>PMID:32185705</ref>. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA4 transmits an inhibitory signal to T cells,[10][11][12][7] whereas CD28 transmits a stimulatory signal.[13][14] CTLA4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4. | '''CTLA4''' or '''Cytotoxic T-Lymphocyte Associated protein 4''' or '''CD152''' is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells<ref>PMID:32185705</ref>. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA4 transmits an inhibitory signal to T cells,[10][11][12][7] whereas CD28 transmits a stimulatory signal.[13][14] CTLA4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4. | ||
See also [[CTLA4 Gene (Protein Coding) | See also [[CTLA4 Gene (Protein Coding) Cytotoxic T-Lymphocyte Associated Protein 4]]. | ||
== Disease == | == Disease == | ||
| Line 22: | Line 21: | ||
[[2x44]], [[3osk]] - hCTLA-4 - human <br /> | [[2x44]], [[3osk]] - hCTLA-4 - human <br /> | ||
[[1ah1]] - hCTLA-4 - NMR<br /> | [[1ah1]] - hCTLA-4 - NMR<br /> | ||
[[5ggv]], [[5tru]], [[5xj3]], [[6rp8]], [[6xy2]], [[7dv4]], [[7elx]], [[7su0]], [[7su1]] - hCTLA-4 + antibody <br /> | [[5ggv]], [[5tru]], [[5xj3]], [[6rp8]], [[6xy2]], [[7dv4]], [[7elx]], [[7su0]], [[7su1]], [[8hit]], [[9dq3]] - hCTLA-4 + antibody <br /> | ||
[[6rpj]], [[6rqm]] - hCTLA-4 + nanobody <br /> | [[6rpj]], [[6rqm]] - hCTLA-4 + nanobody <br /> | ||
[[1i8l]] - hCTLA-4 + CD80<br /> | [[1i8l]] - hCTLA-4 + CD80<br /> | ||
| Line 31: | Line 30: | ||
[[1dqt]], [[5e56]] - mCTLA-4 - mouse<br /> | [[1dqt]], [[5e56]] - mCTLA-4 - mouse<br /> | ||
[[5e5m]] - mCTLA-4 + nanobody <br /> | [[5e5m]] - mCTLA-4 + nanobody <br /> | ||
[[9dq4]], [[9dq5]] - mCTLA-4 + antibody <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||