6xxe: Difference between revisions

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<StructureSection load='6xxe' size='340' side='right'caption='[[6xxe]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
<StructureSection load='6xxe' size='340' side='right'caption='[[6xxe]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6xxe]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XXE FirstGlance]. <br>
<table><tr><td colspan='2'>[[6xxe]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XXE FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxe OCA], [http://pdbe.org/6xxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xxe RCSB], [http://www.ebi.ac.uk/pdbsum/6xxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxe ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxe OCA], [https://pdbe.org/6xxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xxe RCSB], [https://www.ebi.ac.uk/pdbsum/6xxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxe ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/PILA5_THET2 PILA5_THET2] Plays an essential role in forming the main structure of the narrow T4P pili that participates in twitching motility.<ref>PMID:32376942</ref>
Type IV pili are flexible filaments on the surface of bacteria, consisting of a helical assembly of pilin proteins. They are involved in bacterial motility (twitching), surface adhesion, biofilm formation and DNA uptake (natural transformation). Here, we use cryo-electron microscopy and mass spectrometry to show that the bacterium Thermus thermophilus produces two forms of type IV pilus ('wide' and 'narrow'), differing in structure and protein composition. Wide pili are composed of the major pilin PilA4, while narrow pili are composed of a so-far uncharacterized pilin which we name PilA5. Functional experiments indicate that PilA4 is required for natural transformation, while PilA5 is important for twitching motility.


Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium.,Neuhaus A, Selvaraj M, Salzer R, Langer JD, Kruse K, Kirchner L, Sanders K, Daum B, Averhoff B, Gold VAM Nat Commun. 2020 May 6;11(1):2231. doi: 10.1038/s41467-020-15650-w. PMID:32376942<ref>PMID:32376942</ref>
==See Also==
 
*[[Pilin 3D structures|Pilin 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6xxe" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thet2]]
[[Category: Thermus thermophilus HB27]]
[[Category: Gold, V A.M]]
[[Category: Gold VAM]]
[[Category: Neuhaus, A]]
[[Category: Neuhaus A]]
[[Category: Cell adhesion]]
[[Category: Type iv pilin glycosylation twitching motility]]

Latest revision as of 08:58, 21 November 2024

CryoEM structure of the type IV pilin PilA5 from Thermus thermophilusCryoEM structure of the type IV pilin PilA5 from Thermus thermophilus

Structural highlights

6xxe is a 16 chain structure with sequence from Thermus thermophilus HB27. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.49Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PILA5_THET2 Plays an essential role in forming the main structure of the narrow T4P pili that participates in twitching motility.[1]

See Also

References

  1. ↑ Neuhaus A, Selvaraj M, Salzer R, Langer JD, Kruse K, Kirchner L, Sanders K, Daum B, Averhoff B, Gold VAM. Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium. Nat Commun. 2020 May 6;11(1):2231. doi: 10.1038/s41467-020-15650-w. PMID:32376942 doi:http://dx.doi.org/10.1038/s41467-020-15650-w

6xxe, resolution 3.49Å

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