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| **[[3rsr]] – yRNR R1 + inhibitor<br /> | | **[[3rsr]] – yRNR R1 + inhibitor<br /> |
| **[[1qfn]] - EcRNR R1 + glutaredoxin 1<br /> | | **[[1qfn]] - EcRNR R1 + glutaredoxin 1<br /> |
| **[[7agj]] - AaRNR R1 + ATP – "Aquifex aeolicus''<br /> | | **[[7agj]] - AaRNR R1 + ATP – ''Aquifex aeolicus''<br /> |
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| *RNR small subunit R2 | | *RNR small subunit R2 |
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| **[[6cwo]], [[6cwq]] - FjRNR + Mn – ''Flavobacterium johnsoniae''<br /> | | **[[6cwo]], [[6cwq]] - FjRNR + Mn – ''Flavobacterium johnsoniae''<br /> |
| **[[6gp2]], [[6gp3]] - RNR R2 – ''Mesoplasma florum''<br /> | | **[[6gp2]], [[6gp3]] - RNR R2 – ''Mesoplasma florum''<br /> |
| **[[7aik]], [[7ail]] - AaRNR R2 <br /> | | **[[7aik]], [[7ail]], [[7q39]], [[7q3c]] - AaRNR R2 <br /> |
| **[[6y2n]] - RNR R2 – ''Saccharopolyspora erythraea''<br /> | | **[[6y2n]] - RNR R2 – ''Saccharopolyspora erythraea''<br /> |
| **[[6ebz]], [[6ebz]] - AuRNR R2 – ''Aerococcus urinae''<br /> | | **[[6ebz]], [[6ebz]] - AuRNR R2 – ''Aerococcus urinae''<br /> |
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| **[[7mdi]] - RNR R1 + R2 + CDP + DTP – ''Neisseria gonorrhoea'' - Cryo EM<br /> | | **[[7mdi]] - RNR R1 + R2 + CDP + DTP – ''Neisseria gonorrhoea'' - Cryo EM<br /> |
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| *'''Class Ib RNR''' ; NrdE – large subunit; NrdF – small subunit; NrdI | | *'''Class Ib RNR''' ; NrdE – large subunit; NrdF – small subunit; NrdI – FMN containing flavoprotein |
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| **[[6cgm]] - BaRNR NrdE – ''Bacillus subtilis''<br /> | | **[[6cgm]] - BaRNR NrdE – ''Bacillus subtilis''<br /> |
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| **[[4bmu]] - BcRNR NrdF + Mn<br /> | | **[[4bmu]] - BcRNR NrdF + Mn<br /> |
| **[[4bmo]], [[4bmp]] - BcRNR NrdF + NrdI + Fe + FMN<br /> | | **[[4bmo]], [[4bmp]] - BcRNR NrdF + NrdI + Fe + FMN<br /> |
| | **[[7z3d]], [[7z3e]] - BcRNR NrdF + NrdI + Mn + FMN<br /> |
| **[[4m1f]] - EcRNR NrdF<br /> | | **[[4m1f]] - EcRNR NrdF<br /> |
| **[[3n37]] - EcRNR NrdF + Mn<br /> | | **[[3n37]] - EcRNR NrdF + Mn<br /> |
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| **[[3mjo]] - CaRNR NrdF + Mn - ''Corynebacterium ammoniagenes'' <br /> | | **[[3mjo]] - CaRNR NrdF + Mn - ''Corynebacterium ammoniagenes'' <br /> |
| **[[1kgn]], [[1kgo]], [[1kgp]], [[1oqu]], [[3dhz]] - CaRNR NrdF + Fe<br /> | | **[[1kgn]], [[1kgo]], [[1kgp]], [[1oqu]], [[3dhz]] - CaRNR NrdF + Fe<br /> |
| **[[6ebq]] - AuRNR NrdI + FMN<br />
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| *Class Id RNR; NrdB – small subunit | | *Class Id RNR or ribonucleotide-diphosphate reductase; NrdB – small subunit |
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| **[[6sf4]], [[6sf5]] - RNR β subunit – ''Leeuwenhoekiella blandensis''<br /> | | **[[6sf4]], [[6sf5]] - RNR β subunit – ''Leeuwenhoekiella blandensis''<br /> |
| **[[6dqw]] - FjRNR α subunit <br /> | | **[[6cwo]], [[6cwq]] - FjRNR b subunit 1-324 + Mn – ''Flavobacterium johnsoniae''<br /> |
| | **[[8dq4]], [[8dq5]] - FjRNR b subunit (mutant) + Mn <br /> |
| | **[[6dqw]] - FjRNR a subunit 1-565<br /> |
| | **[[6dqx]] - RNR a subunit – ''Actinobacillus ureae''<br /> |
| | **[[8dq3]] - RNR b subunit + Mn – ''Aggregatibacter actinomycetemcomitans''<br /> |
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| | *Class Ie RNR |
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| | **[[6ebo]] - AuRNR beta subunit - ''Aerococcus urinae'' <br /> |
| | **[[7mms]], [[7mmt]], [[7mmu]], [[7mmv]], [[7mmw]] - AuRNR beta subunit + Cu<br /> |
| | **[[6ebp]] - AuRNR beta subunit + L-Dopa<br /> |
| | **[[6ebz]] - AuRNR beta subunit + L-Dopa + SCN<br /> |
| | **[[6ebq]] - AuRNR NrdI + FMN<br /> |
| | **[[7mmp]], [[7mmq]] - AuRNR + NrdI + FMN<br /> |
| | **[[7mmr]] - AuRNR + NrdI + FMN + Cu<br /> |
| **[[6dqx]] - RNR α subunit – ''Actinobacillus ureae''<br /> | | **[[6dqx]] - RNR α subunit – ''Actinobacillus ureae''<br /> |
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| **[[7b9p]], [[7b9q]] – RNR + DTP – ''Rhodobacter sphaeroides'' <br /> | | **[[7b9p]], [[7b9q]] – RNR + DTP – ''Rhodobacter sphaeroides'' <br /> |
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| | *Anaerobic ribonucleotide-triphosphate reductase |
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| | **[[8p23]], [[8p27]], [[8p28]], [[8p2c]], [[8p2d]], [[8p2s]], [[8p39]] – ARNR + DTP – ''Segatella copri'' - Cryo EM<br /> |
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| | *RNR |
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| | **[[7urg]] – RNR + TTP – ''Synechococcus'' phage – Cryo EM <br /> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
3D Structures of Ribonucleotide reductase3D Structures of Ribonucleotide reductase
Updated on 08-August-2024
{"openlevels":0}
- Class Ia ribonucleotide reductase
- Ribonucleotide reductase large subunit R1
- 1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
- 1rlr - EcRNR R1 – Escherichia coli
- 1mrr - EcRNR R1 + Mn
- 5r1r, 6r1r, 7r1r, 1r1r – EcRNR R1 (mutant) + R2
- Ribonucleotide reductase large subunit complex
- 3hnc – hRNR M1 + TTP – human
- 3hnd – hRNR M1 + GDP + TTP
- 3hne, 3hnf – hRNR M1 + ATP + TTP
- 2wgh, 5d1y - hRNR M1 + ATP + Mg
- 6aui - hRNR M1 + ATP + CDP
- 5tus, 4x3v, 6l3r, 6l7l, 6lkm - hRNR M1 + inhibitor + TTP
- 3paw - yRNR R1 + ATP
- 3k8t - yRNR R1 + ADP analog
- 3s87 - yRNR R1 + ADP + GTP
- 3s8a - yRNR R1 (mutant) + GTP
- 3tba - yRNR R1 (mutant) + GTP + ADP
- 3s8b - yRNR R1 + AMPPNP + CDP
- 3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
- 2zlf, 2zlg - yRNR R1 + peptide
- 2eud - yRNR R1 + ligand
- 3rsr – yRNR R1 + inhibitor
- 1qfn - EcRNR R1 + glutaredoxin 1
- 7agj - AaRNR R1 + ATP – Aquifex aeolicus
- RNR small subunit R2
- 3hf1, 2vux, 2uw2, 4djn, 3olj – hRNR M2
- 3vpm, 3vpn, 3vpo – hRNR M2 (mutant)
- 1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
- 1smq, 1sms – yRNR 2
- 1jk0 – yRNR Y2+Y4
- 2xof, 1av8, 1rib – EcRNR R2 + Fe2O
- 2alx, 1jqc, 1jpr - EcRNR R2 + Mn
- 1piy, 1r65, 1mxr, 1xik, 7ai8, 7ai9, 7bet - EcRNR R2 + Fe
- 1piz, 1pj0, 1pj1, 1pim, 1piu, 1biq, 1pfr - EcRNR R2 (mutant) + Fe
- 1yfd, 2av8 - EcRNR R2 (mutant) + Fe2O
- 1pm2 - EcRNR R2 (mutant) + Mn
- 2p1i – RNR R2 – Plasmodium yoelii
- 2o1z - RNR R2 – Plasmodium vivax
- 4d8f, 4d8g, 4m1i - CtRNR R2 + Fe + Mn
- 1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
- 2ani - CtRNR R2 (mutant) + Fe + Pb
- 4m1h - CtRNR R2
- 1uzr – MtRNR R2 – Mycobacterium tuberculosis
- 2rcc – RNR – Bacillus halodurans
- 4n83 - SsRNR + Mn
- 4hr5 - GkRNR – Geobacillus kaustophilus
- 5omj, 5omk - GkRNR + Fe
- 4hr0, 4hr4 - GkRNR + Fe + Mn
- 6f6c, 6f6e, 6f6f, 6f6g, 6f6h, 6f6k, 6qjv, 6qk0, 6qk1, 6qk2 - GkRNR (mutant) + Fe + Mn
- 6cwo, 6cwq - FjRNR + Mn – Flavobacterium johnsoniae
- 6gp2, 6gp3 - RNR R2 – Mesoplasma florum
- 7aik, 7ail, 7q39, 7q3c - AaRNR R2
- 6y2n - RNR R2 – Saccharopolyspora erythraea
- 6ebz, 6ebz - AuRNR R2 – Aerococcus urinae
- 6qrz - RNR R2 – Sulfolobus acidocaldarius
- 6zjk - RNR R2 – Clostridium botulinum
- Ribonucleotide reductase small subunit complex
- 1w69 – mRNR R2 + acetate
- 1rsr, 1rsv - EcRNR R2 (mutant) + Fe + N3
- 1rnr – EcRNR R2 (mutant) + Fe + dopa
- 5ci4 – EcRNR R2 (mutant) + Fe2O
- 5ci3, 5ci0, 5ci1, 5ci2 – EcRNR R2 (mutant) + fluoro-tyrosine + Fe2O
- 6cwp – FjRNR + Mn + peptide
- 4xbw – GkRNR + Mn
- 6i94 – GkRNR (mutant) + Mn
- 5dco, 4xb9, 4xbv – GkRNR + Fe
- 6i93 – GkRNR (mutant) + Fe
- 5dcr, 5dcs – GkRNR + Mn + Fe
- 6i90, 6i92, 6i95, 6f65, 6f6b, 6f6l, 6f6m, 5ekb, 6qjv, 6qk0, 6qk1, 6qk2 – GkRNR (mutant) + Mn + Fe
- 4ac8 – MtRNR + Mn + Fe
- Ribonucleotide reductase small+large subunit
- 1r1r, 5r1r, 6r1r, 7r1r, 1r1r – EcRNR R1 (mutant) + R2
- 3uus - EcRNR R1+ R2 + Fe + ATP
- 4erm - EcRNR R1+ R2 + Fe2O + ATP + ADP
- 4erp - EcRNR R1+ R2 + Fe2O + ATP
- 2xak, 2xap, 2xo4, 2xo5 - EcRNR R1 modified+ R2 peptide
- 2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) modified + R2 peptide
- 5cns, 5cnt, 5cnv, 5cnu - EcRNR R1 + R2 + Fe2O + 2 nucleotides
- 2r1r - EcRNR R1 + R2 + TTP
- 3r1r - EcRNR R1 + R2 + AMPPNP
- 6w4x - EcRNR R1 + R2 + GDP + TTP – Cryo EM
- 4r1r - EcRNR R1 + R2 + GDP + TTP
- 2bq1 - StRNR R1+ R2
- 5im3 - RNR + dATP – Pseudomonas aeruginosa
- 7mdi - RNR R1 + R2 + CDP + DTP – Neisseria gonorrhoea - Cryo EM
- Class Ib RNR ; NrdE – large subunit; NrdF – small subunit; NrdI – FMN containing flavoprotein
- 6cgm - BaRNR NrdE – Bacillus subtilis
- 6qo5, 6qo7, 6qo8, 6qo9, 6qob, 6tqv, 6tqw, 6tqx - BaRNR NrdF
- 6tqy, 6tqz - BaRNR NrdF (mutant)
- 4dr0 - BaRNR NrdF + Mn
- 6myx - BaRNR NrdE + DTP – Cryo EM
- 6mv9 - BaRNR NrdE + TTP + ADP
- 6mt9, 6mve - BaRNR NrdE + TTP + ADP + ATP
- 6mw3 - BaRNR NrdE + NrdF + DTP – Cryo EM
- 6cgn, 6cgl - BaRNR NrdE + AMP derivative
- 1pem - StRNR NrdE – Salmonella typhimurium
- 1peo, 1peq, 1peu - StRNR NrdE + nucleotide
- 2bq1 - StRNR NrdE + NrdF + Fe + GTP
- 1r2f - StRNR NrdF + Fe
- 2r2f - StRNR NrdF + Fe2O
- 4dr0 - BaRNR NrdF + Mn
- 4bmq, 4bmr, 4bmt - BcRNR NrdF + Fe – Bacillus cereus
- 4bmu - BcRNR NrdF + Mn
- 4bmo, 4bmp - BcRNR NrdF + NrdI + Fe + FMN
- 7z3d, 7z3e - BcRNR NrdF + NrdI + Mn + FMN
- 4m1f - EcRNR NrdF
- 3n37 - EcRNR NrdF + Mn
- 3n38 - EcRNR NrdF + Fe
- 3n39, 3n3a - EcRNR NrdF + NrdI + Mn + FMN
- 3n3b - EcRNR NrdF + NrdI + Mn + FMN + Fe2O
- 4n82 – SsRNR + FMN – Streptococcus sanguinis
- 4n83 - SsRNR NrdF + Mn
- 3mjo - CaRNR NrdF + Mn - Corynebacterium ammoniagenes
- 1kgn, 1kgo, 1kgp, 1oqu, 3dhz - CaRNR NrdF + Fe
- Class Id RNR or ribonucleotide-diphosphate reductase; NrdB – small subunit
- 6sf4, 6sf5 - RNR β subunit – Leeuwenhoekiella blandensis
- 6cwo, 6cwq - FjRNR b subunit 1-324 + Mn – Flavobacterium johnsoniae
- 8dq4, 8dq5 - FjRNR b subunit (mutant) + Mn
- 6dqw - FjRNR a subunit 1-565
- 6dqx - RNR a subunit – Actinobacillus ureae
- 8dq3 - RNR b subunit + Mn – Aggregatibacter actinomycetemcomitans
- Class Ie RNR
- 6ebo - AuRNR beta subunit - Aerococcus urinae
- 7mms, 7mmt, 7mmu, 7mmv, 7mmw - AuRNR beta subunit + Cu
- 6ebp - AuRNR beta subunit + L-Dopa
- 6ebz - AuRNR beta subunit + L-Dopa + SCN
- 6ebq - AuRNR NrdI + FMN
- 7mmp, 7mmq - AuRNR + NrdI + FMN
- 7mmr - AuRNR + NrdI + FMN + Cu
- 6dqx - RNR α subunit – Actinobacillus ureae
- Class II ribonucleotide reductase
- 1xjf, 4col – TmRNR + DATP – Thermotoga maritima
- 4coi, 4com, 4con – TmRNR
- 1xjg, 1xjk, 1xje, 1xjn, 4coj - TmRNR + 2 nucleotides
- 1xjj - TmRNR + GTP
- 1xjm - TmRNR + TTP
- 3o0n - TmRNR + TTP + Co + Mg + deoxyadenosine + B12
- 3o0o - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12
- 3o0q - TmRNR + TTP + GDP + Mg + adenosine
- 1l1l – RNR (mutant) – Lactobacillus leichmannii
- Class III ribonucleotide reductase
- 1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
- 1h7b – T4RNR (mutant)
- 4u3e – TmRNR large subunit
- Vitamin B12-dependent RNR
- 7b9p, 7b9q – RNR + DTP – Rhodobacter sphaeroides
- Anaerobic ribonucleotide-triphosphate reductase
- RNR
- 7urg – RNR + TTP – Synechococcus phage – Cryo EM