6row: Difference between revisions
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==Haemonchus galactose containing glycoprotein complex== | |||
<StructureSection load='6row' size='340' side='right'caption='[[6row]], [[Resolution|resolution]] 4.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6row]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6row FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6row OCA], [https://pdbe.org/6row PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6row RCSB], [https://www.ebi.ac.uk/pdbsum/6row PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6row ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/O76751_HAECO O76751_HAECO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies on anthelmintic drugs to which roundworms are becoming increasingly resistant. An alternative approach is control by vaccination and 'hidden antigens', components of the worm gut not encountered by the infected host, have been exploited to produce Barbervax, the first commercial vaccine for a gut dwelling nematode of any host. Here we present the structure of H-gal-GP, a hidden antigen from Haemonchus contortus, the Barber's Pole worm, and a major component of Barbervax. We demonstrate its novel architecture, subunit composition and topology, flexibility and heterogeneity using cryo-electron microscopy, mass spectrometry, and modelling. Importantly, we demonstrate that complexes with the same architecture are present in other Strongylid roundworm parasites including human hookworm. This suggests a common ancestry and the potential for development of a unified hidden antigen vaccine. | |||
Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.,Scarff CA, Thompson RF, Newlands GFJ, Jamson AH, Kennaway C, da Silva VJ, Rabelo EM, Song CF, Trinick J, Smith WD, Muench SP PLoS Pathog. 2020 Apr 9;16(4):e1008465. doi: 10.1371/journal.ppat.1008465., eCollection 2020 Apr. PMID:32271834<ref>PMID:32271834</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6row" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Pepsin|Pepsin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Haemonchus contortus]] | |||
[[Category: Large Structures]] | |||
[[Category: Jamson H]] | |||
[[Category: Kennaway C]] | |||
[[Category: Muench SP]] | |||
[[Category: Newlands GFJ]] | |||
[[Category: Rabelo EM]] | |||
[[Category: Scarff CA]] | |||
[[Category: Smith WD]] | |||
[[Category: Song CF]] | |||
[[Category: Thompson RF]] | |||
[[Category: Trinick J]] | |||
[[Category: Da Silva VJ]] | |||