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Beta-lactamase 3D structures: Difference between revisions

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*β-lactamase class A
*β-lactamase class A


**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]], [[7u6q]], [[8gii]] - EcBlac A Tem-1- Escherichia coli
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]], [[7u6q]], [[8gii]] - EcBlac A Tem-1- ''Escherichia coli''
**[[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[3dtm]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]], [[8ddz]], [[8gij]], [[8rqu]] - EcBlac A Tem-1 (mutant)   
**[[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[3dtm]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]], [[8ddz]], [[8gij]], [[8rqu]] - EcBlac A Tem-1 (mutant)   
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br />
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br />
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**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
**[[1o7e]], [[1n4o]], [[5ne2]], [[7uhr]], [[7uhs]], [[7uht]], [[8iso]] – StmBlac A – Stenotrophonas maltophilia
**[[1o7e]], [[1n4o]], [[5ne2]], [[7uhr]], [[7uhs]], [[7uht]], [[8iso]] – StmBlac A – ''Stenotrophonas maltophilia''
**[[1htz]] – KpBlac A Tem-52 – Klebsiella pneumoniae
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''
**[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1
**[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant)  
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant)  
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**[[6nfd]] - KpBlac A Shv-11 (mutant) <br />
**[[6nfd]] - KpBlac A Shv-11 (mutant) <br />
**[[5haq]], [[5hap]] - KpBlac A (mutant) <br />
**[[5haq]], [[5hap]] - KpBlac A (mutant) <br />
**[[1hzo]] – Blac A – Proteus vulgaris
**[[1hzo]] – Blac A – ''Proteus vulgaris''
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - Staphylococcus aureus
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - ''Staphylococcus aureus''
**[[3blm]] – SaBlac A
**[[3blm]] – SaBlac A
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant)  – Bacillus licheniformis
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant)  – ''Bacillus licheniformis''
**[[2blm]], [[3sh7]] – BlBlac A
**[[2blm]], [[3sh7]] – BlBlac A
**[[2cc1]] – Blac A – Mycobacterium fortuitum
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''
**[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - Citrobacter sedlakii
**[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – Enterobacter cloacae<br />
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[4c6y]], [[4c75]], [[5fqm]], [[6tww]], [[6txd]], [[6ty6]], [[6yrs]] – Blac – synthetic<br />
**[[4c6y]], [[4c75]], [[5fqm]], [[6tww]], [[6txd]], [[6ty6]], [[6yrs]] – Blac – synthetic<br />
**[[5tfq]] – Blac – Bacterioides cellulosilyticus<br />
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - Burkholderia thailandensis<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
**[[6afm]], [[6afo]] - BtBlac A (mutant)<br />
**[[6afm]], [[6afo]] - BtBlac A (mutant)<br />
**[[4yfm]] – Blac – Mycobacterium abscessus<br />
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br />
**[[6ni1]] – BsBlac A – Bacillus subtilis<br />
**[[6ni1]] – BsBlac A – ''Bacillus subtilis''<br />
**[[6niq]] – Blac A – Rhodopseudomonas palustris<br />
**[[6niq]] – Blac A – ''Rhodopseudomonas palustris''<br />
**[[6nj1]] – Blac A – Clostridium kluyveri<br />
**[[6nj1]] – Blac A – ''Clostridium kluyveri''<br />
**[[6b6a]], [[6b6b]], [[6b69]], [[6b68]], [[6b5x]], [[6n14]], [[8gcs]], [[8gcv]], [[8rg2]] – MtBlac – Mycobacterium tuberculosis<br />
**[[6b6a]], [[6b6b]], [[6b69]], [[6b68]], [[6b5x]], [[6n14]], [[8gcs]], [[8gcv]], [[8rg2]] – MtBlac – ''Mycobacterium tuberculosis''<br />
**[[8oe1]], [[8oe5]], [[8rii]] - MtBlac A (mutant)<br />
**[[8oe1]], [[8oe5]], [[8rii]] - MtBlac A (mutant)<br />
**[[6v6n]] - Blac A (mutant) – Agrobacterium tumefaciens <br />
**[[6v6n]] - Blac A (mutant) – ''Agrobacterium tumefaciens'' <br />
**[[6w34]] – BcBlac A (mutant) - Bacillus cereus<br />
**[[6w34]] – BcBlac A (mutant) - ''Bacillus cereus''<br />
**[[6wip]] – Blac A – Micromonospora aurantiaca<br />
**[[6wip]] – Blac A – ''Micromonospora aurantiaca''<br />
**[[6l3s]] – MmBlac Imp-27 – ''Morganella morganii''<br />
**[[6l3s]] – MmBlac Imp-27 – ''Morganella morganii''<br />
**[[9bzn]] – BbBlac A – Bordetella bronchiseptica<br />
**[[9bzn]] – BbBlac A – ''Bordetella bronchiseptica''<br />
**[[8j6y]], [[8sdl]] - PaBlac A - Pseudomonas aeruginosa <br />
**[[8j6y]], [[8sdl]] - PaBlac A - ''Pseudomonas aeruginosa'' <br />
**[[8sdn]] - PaBlac A (mutant)<br />
**[[8sdn]] - PaBlac A (mutant)<br />
**[[8qnn]] – Blac A – Nocardia cyriacigeorgica<br />
**[[8qnn]] – Blac A – ''Nocardia cyriacigeorgica''<br />
**[[8iwv]] – YeBlac A – Yersinia enterocolitica<br />
**[[8iwv]] – YeBlac A – ''Yersinia enterocolitica''<br />


*β-lactamase class A binary complex
*β-lactamase class A binary complex
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**[[5l2f]] - AbBlac A + antibiotic<br />
**[[5l2f]] - AbBlac A + antibiotic<br />
**[[5ne3]], [[7uhj]], [[7uhk]], [[7uhm]], [[7uhn]], [[7uho]], [[7uhp]], [[7uhq]], [[7zo2]], [[7zo3]], [[7zo4]], [[7zo5]], [[7zo6]], [[7zo7]] - StmBlac A + antibiotic <br />
**[[5ne3]], [[7uhj]], [[7uhk]], [[7uhm]], [[7uhn]], [[7uho]], [[7uhp]], [[7uhq]], [[7zo2]], [[7zo3]], [[7zo4]], [[7zo5]], [[7zo6]], [[7zo7]] - StmBlac A + antibiotic <br />
**[[6dmh]] - SfBlac A (mutant) + antibiotic - Serratia fonticola<br />
**[[6dmh]] - SfBlac A (mutant) + antibiotic - ''Serratia fonticola''<br />
**[[6b6f]], [[6b6e]], [[6b6d]], [[6b6c]], [[6b5y]], [[8bv4]], [[8ebi]], [[8ebr]], [[8gct]], [[8gcx]] – MtBlac + antibiotic<br />
**[[6b6f]], [[6b6e]], [[6b6d]], [[6b6c]], [[6b5y]], [[8bv4]], [[8ebi]], [[8ebr]], [[8gct]], [[8gcx]] – MtBlac + antibiotic<br />
**[[8btv]], [[8btw]] – MtBlac A (mutant) + antibiotic<br />
**[[8btv]], [[8btw]] – MtBlac A (mutant) + antibiotic<br />
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**[[6ts9]] - PaESBL A Ges-5<br />
**[[6ts9]] - PaESBL A Ges-5<br />
**[[5gs8]] – SmESBL Tla-3 <br />
**[[5gs8]] – SmESBL Tla-3 <br />
**[[6bn3]] – SeESBL Ctx-M-151 – Salmonela enterica<br />
**[[6bn3]] – SeESBL Ctx-M-151 – ''Salmonela enterica''<br />


*Extended-spectrum β-lactamase class A binary complex
*Extended-spectrum β-lactamase class A binary complex
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**[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant)  
**[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant)  
**[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip
**[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – Bacillus anthracis
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''


*beta-lactamase class B (Zn containing) or metallo-beta-lactamase or NDM
*beta-lactamase class B (Zn containing) or metallo-beta-lactamase or NDM
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**[[2m5c]] - BcBlac B – NMR<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]], [[3knr]], [[3kns]] - BcBlac B (mutant)  
**[[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]], [[3knr]], [[3kns]] - BcBlac B (mutant)  
**[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – Bacterioides fragilis
**[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – ''Bacterioides fragilis''
**[[2znb]] - BfBlac B + Cd
**[[2znb]] - BfBlac B + Cd
**[[3znb]] – BfBlac B + Zn + Hg
**[[3znb]] – BfBlac B + Zn + Hg
**[[4znb]] - BfBlac B (mutant)  
**[[4znb]] - BfBlac B (mutant)  
**[[1k07]] – FgBlac B - Fluoribacter gormanii
**[[5wck]] – FgBlac B - ''Fluoribacter gormanii''
**[[1l9y]] - FgBlac B (mutant)  
**[[1l9y]] - FgBlac B (mutant)  
**[[5n5g]] - PaBlac B Vim-1<br />
**[[5n5g]] - PaBlac B Vim-1<br />
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**[[6r79]], [[6yi4]] - PaBlac Imp-13 <br />
**[[6r79]], [[6yi4]] - PaBlac Imp-13 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
**[[5ev6]], [[5y5b]], [[7dtm]] - SmBlac Imp-1 – Serratia marcescens<br />
**[[5ev6]], [[5y5b]], [[7dtm]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
**[[1wuo]], [[1wup]], [[7dtn]] - SmBlac Imp-1 (mutant)  
**[[1wuo]], [[1wup]], [[7dtn]] - SmBlac Imp-1 (mutant)  
**[[3vpe]] - SmBlac Smb-1<br />
**[[3vpe]] - SmBlac Smb-1<br />
**[[5fdh]] - SmBlac Oxa-405<br />
**[[5fdh]] - SmBlac Oxa-405<br />
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – Thermus thermophilus
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''
**[[2zzi]] – TtBlac B  + Fe
**[[2zzi]] – TtBlac B  + Fe
**[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B
**[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B
**[[2qin]], [[2qjs]] - StmBlac B (mutant)  
**[[2qin]], [[2qjs]] - StmBlac B (mutant)  
**[[2gmn]], [[3lvz]] – BjBlac B – Bradyrhizobium japonicum
**[[2gmn]], [[3lvz]] – BjBlac B – ''Bradyrhizobium japonicum''
**[[2p4z]] – Blac B – Thermoanaerobacter tengcongensis
**[[2p4z]] – Blac B – ''Thermoanaerobacter tengcongensis''
**[[3l6n]] – Blac B – Chryseobacter indolegenes
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''
**[[3r2u]] – SaBlac B
**[[3r2u]] – SaBlac B
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i]], [[5k4k]], [[5k4m]], [[5k4n]], [[5jqj]], [[5xp9]], [[5zgi]], [[5nbk]], [[6cac]], [[6ex7]], [[6lhe]], [[6twt]] – KpBlac B Ndm-1 + metal ion
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5xp9]], [[5zgi]], [[5nbk]], [[6cac]], [[6ex7]], [[6lhe]], [[6twt]] – KpBlac B Ndm-1 + metal ion
**[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br />
**[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant)  
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant)  
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**[[6bm9]] – EcBlac B Vim-2<br />
**[[6bm9]] – EcBlac B Vim-2<br />
**[[7xhw]] - EcBlac Imp-1 <br />
**[[7xhw]] - EcBlac Imp-1 <br />
**[[6lvj]], [[7wzu]] - EcBlac Imp-6 <br />
**[[7xhx]], [[7wzu]] - EcBlac Imp-6 <br />
**[[6skp]], [[6skq]], [[6skr]] - EcBlac Oxa-10 <br />
**[[6skp]], [[6skq]], [[6skr]] - EcBlac Oxa-10 <br />
**[[6ovz]] - EcBlac <br />
**[[6ovz]] - EcBlac <br />
**[[2yz3]] – Blac Vim-2 – Pseudomonas putida
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''
**[[3sd9]] – SfBlac B  
**[[3sd9]] – SfBlac B  
**[[4ubq]] - AbBlac Imp-2 <br />
**[[4ubq]] - AbBlac Imp-2 <br />
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**[[5a87]] - KpBlac B <br />
**[[5a87]] - KpBlac B <br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4wd6]] – PsBlac Dim-1 – Pseudomonas stutzeri<br />
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
**[[5iqk]], [[7byq]], [[7bz1]], [[7bz3]], [[7bz4]], [[7bzi]] – Blac – uncultured<br />
**[[5iqk]], [[7byq]], [[7bz1]], [[7bz3]], [[7bz4]], [[7bzi]] – Blac – uncultured<br />
**[[5ctn]], [[5ctm]] – Blac – Bacillus pumilus<br />
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
**[[4ysb]] – Blac + Fe – Myxococcus xanthus<br />
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
**[[6cqs]] – Blac + Zn – Sediminispirochaeta smaragdinae<br />
**[[6cqs]] – Blac + Zn – ''Sediminispirochaeta smaragdinae''<br />
**[[6dn4]] – CsBlac – Cronobacter sakazakii<br />
**[[6dn4]] – CsBlac – ''Cronobacter sakazakii''<br />
**[[6dq2]], [[6dqh]], [[6dr8]], [[6nc5]] – CsBlac (mutant)<br />
**[[6dq2]], [[6dqh]], [[6dr8]], [[6nc5]] – CsBlac (mutant)<br />
**[[6mfi]] – Blac Mim-2 – Simiduia agarivorans<br />
**[[6mfi]] – Blac Mim-2 – ''Simiduia agarivorans''<br />
**[[6t5l]] – Blac B1 Myo-1 – Myroides odoratimimus<br />
**[[6t5l]] – Blac B1 Myo-1 – ''Myroides odoratimimus''<br />
**[[6v54]], [[6v5m]], [[6v70]], [[6v71]] – HbBlac (mutant) – Hirschia baltica<br />
**[[6v54]], [[6v5m]], [[6v70]], [[6v71]] – HbBlac (mutant) – ''Hirschia baltica''<br />
**[[6v72]], [[6v73]] – ElBlac – Erythrobacter litoralis<br />
**[[6v72]], [[6v73]] – ElBlac – ''Erythrobacter litoralis''<br />
**[[6jv4]] - VaBlac Vmb-1 – Vibrio alginolyticus<br />
**[[6jv4]] - VaBlac Vmb-1 – ''Vibrio alginolyticus''<br />


*beta-lactamase class B binary complex with antibiotic
*beta-lactamase class B binary complex with antibiotic
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**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
**[[2aio]], [[7a63]] – StmBlac B + antibiotic
**[[2aio]], [[7a63]] – StmBlac B + antibiotic
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]], [[5o2f]], [[5zge]], [[6jkb]], [[8gpc]], [[8gpe]] – KpBlac B Ndm-1+ antibiotic
**[[5zge]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]], [[5o2f]], [[6jkb]], [[8gpc]], [[8gpe]] – KpBlac B Ndm-1+ antibiotic
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
Line 305: Line 305:


**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor
**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor
**[[1jt1]] – FgBlac + captopril  
**[[5w90]] – FgBlac + captopril  
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]], [[7yh9]], [[7yha]], [[8jao]] - PaBlac B Imp-1 + inhibitor
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]], [[7yh9]], [[7yha]], [[8jao]] - PaBlac B Imp-1 + inhibitor
**[[5n5h]], [[7afy]], [[7ayj]], [[7uya]], [[7uyb]], [[7uyc]], [[8p8y]], [[8p8z]], [[8p92]], [[8p93]], [[8p95]], [[8p9p]], [[8p9q]], [[8p9s]], [[8p9t]], [[8pa3]], [[8pa4]], [[8pa5]], [[8pa7]], [[8paa]], [[8pab]], [[8pac]], [[8pad]], [[8pah]], [[8pal]], [[8pam]], [[8pan]], [[8pao]], [[8pb0]], [[8pb2]], [[8pg2]], [[8pg3]], [[8pg4]], [[8pg5]], [[8pg6]], [[8pg7]], [[8pg8]], [[8pg9]], [[8pga]], [[8pgb]], [[8pgc]], [[8pgd]], [[8pge]], [[8pgf]], [[8pgg]], [[8pgh]], [[8pgi]], [[8pgj]], [[8pgk]], [[8pgl]], [[8pgm]], [[8pgn]], [[8pgo]], [[8pgp]], [[8pgq]], [[8pgr]], [[8pgs]], [[8pgt]], [[8pgu]], [[8pgv]], [[8pgw]], [[8pgx]], [[8pgy]], [[8pgz]], [[8ph0]], [[8ph1]], [[8ph2]], [[8ph3]], [[9c5p]] - PaBlac B Vim-1 + inhibitor<br />
**[[5n5h]], [[7afy]], [[7ayj]], [[7uya]], [[7uyb]], [[7uyc]], [[8p8y]], [[8p8z]], [[8p92]], [[8p93]], [[8p95]], [[8p9p]], [[8p9q]], [[8p9s]], [[8p9t]], [[8pa3]], [[8pa4]], [[8pa5]], [[8pa7]], [[8paa]], [[8pab]], [[8pac]], [[8pad]], [[8pah]], [[8pal]], [[8pam]], [[8pan]], [[8pao]], [[8pb0]], [[8pb2]], [[8pg2]], [[8pg3]], [[8pg4]], [[8pg5]], [[8pg6]], [[8pg7]], [[8pg8]], [[8pg9]], [[8pga]], [[8pgb]], [[8pgc]], [[8pgd]], [[8pge]], [[8pgf]], [[8pgg]], [[8pgh]], [[8pgi]], [[8pgj]], [[8pgk]], [[8pgl]], [[8pgm]], [[8pgn]], [[8pgo]], [[8pgp]], [[8pgq]], [[8pgr]], [[8pgs]], [[8pgt]], [[8pgu]], [[8pgv]], [[8pgw]], [[8pgx]], [[8pgy]], [[8pgz]], [[8ph0]], [[8ph1]], [[8ph2]], [[8ph3]], [[9c5p]] - PaBlac B Vim-1 + inhibitor<br />
Line 314: Line 314:
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br />
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br />
**[[5fq9]], [[6rtn]] - PaBlac Oxa-10 + inhibitor<br />
**[[5fq9]], [[6rtn]] - PaBlac Oxa-10 + inhibitor<br />
**[[1m2x]] – Blac B + captopril – Elizabethkingia meningoseptica
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]], [[6jed]], [[6jka]], [[6lbl]], [[8z5l]] - SmBlac Imp-1+ inhibitor
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]], [[6jed]], [[6jka]], [[6lbl]], [[8z5l]] - SmBlac Imp-1+ inhibitor
**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br />
**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br />
Line 321: Line 321:
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor  
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor  
**[[3m8t]] – BjBlac B + inhibitor
**[[5wcm]] – BjBlac B + inhibitor
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[4nq7]], [[4tyt]], [[5jmx]], [[6f2n]], [[6ewe]], [[6eum]] - BcBlac B + inhibitor<br />
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]], [[5jmx]], [[6f2n]], [[6ewe]], [[6eum]] - BcBlac B + inhibitor<br />
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[3q6v]] – SfBlac B + glycerol  
**[[3q6v]] – SfBlac B + glycerol  
Line 338: Line 338:
**[[5f1g]], [[5ggw]], [[6g9t]], [[6xg1]] – EcBlac C<br />
**[[5f1g]], [[5ggw]], [[6g9t]], [[6xg1]] – EcBlac C<br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant)  
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant)  
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – Enterobacter aerogenes
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''
**[[2qz6]] – Blac C – Pseudomonas fluorescens
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''
**[[7mqn]] – Blac C – Rhodobacter sphaeroides<br />
**[[7mqn]] – Blac C – ''Rhodobacter sphaeroides''<br />
**[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br />
**[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br />
**[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br />
**[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br />
Line 350: Line 350:
**[[8fqr]] – AbBlac C Adc-212<br />
**[[8fqr]] – AbBlac C Adc-212<br />
**[[8fqt]] – AbBlac C Adc-219<br />
**[[8fqt]] – AbBlac C Adc-219<br />
**[[6fm6]] - Blac C Tru-1 – Aeromonas enteropelogenes<br />
**[[6fm6]] - Blac C Tru-1 – ''Aeromonas enteropelogenes''<br />


*beta-lactamase class C binary complex
*beta-lactamase class C binary complex


**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]], [[6wa7]], [[6xfs]] - EcBlac C + inhibitor
**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]], [[6xfs]] - EcBlac C + inhibitor
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor  
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor  
Line 384: Line 384:
**[[1ko2]] – PaBlac Vim-2
**[[1ko2]] – PaBlac Vim-2
**[[7l5v]], [[7n1m]] - PaBlac D Oxa-935<br />
**[[7l5v]], [[7n1m]] - PaBlac D Oxa-935<br />
**[[1k38]] – Blac D – Salmonella typhimurium
**[[1k38]] – Blac D – ''Salmonella typhimurium''
**[[1m6k]] – EcBlac D
**[[1m6k]] – EcBlac D
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46
Line 397: Line 397:
**[[6nz8]] - AbBlac D Oxa-231<br />
**[[6nz8]] - AbBlac D Oxa-231<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
**[[4ied]] – Blac – Fusobacterium nucleatum<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[5e2f]], [[6w5e]] – BsBlac D <br />
**[[5e2f]], [[6w5e]] – BsBlac D <br />
**[[6nlw]] – Blac D – Shewanella oneidensis<br />
**[[6nlw]] – Blac D – ''Shewanella oneidensis''<br />
**[[6nhs]] – Blac D – Nostoc<br />
**[[6nhs]] – Blac D – Nostoc<br />
**[[6nhu]] – Blac D – Agrobacterium fabrum<br />
**[[6nhu]] – Blac D – ''Agrobacterium fabrum''<br />
**[[6ni0]] – BtBlac D <br />
**[[6ni0]] – BtBlac D <br />
**[[6n1n]] – Blac D – Sebaldella termitidis<br />
**[[6n1n]] – Blac D – ''Sebaldella termitidis''<br />
**[[6ue2]] – Blac D – Peptoclostridium difficile<br />
**[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br />
**[[6wy4]], [[7rl8]] – CdBlac D – Clostridium difficile<br />
**[[6wy4]], [[7rl8]] – CdBlac D – ''Clostridium difficile''<br />
**[[7rlr]] – CdBlac D (mutant) <br />
**[[7rlr]] – CdBlac D (mutant) <br />
**[[6w5g]] – BaBlac D – Bacillus atrophaeus<br />
**[[6w5g]] – BaBlac D – ''Bacillus atrophaeus''<br />
**[[6w5o]] – BaBlac D (mutant) <br />
**[[6w5o]] – BaBlac D (mutant) <br />
**[[7k3m]] – CpBlac D <br />
**[[7k3m]] – CpBlac D <br />
Line 444: Line 444:
**[[7khy]] - KpBlac D Oxa-163 + antibiotic<br />
**[[7khy]] - KpBlac D Oxa-163 + antibiotic<br />
**[[6xj3]], [[8qnz]] - KpBlac D + antibiotic<br />
**[[6xj3]], [[8qnz]] - KpBlac D + antibiotic<br />
**[[8ep6]] – CpBlac + antibiotic – Chitinophaga pinensis<br />
**[[8ep6]] – CpBlac + antibiotic – ''Chitinophaga pinensis''<br />


*AmpC beta-lactamase
*AmpC beta-lactamase
Line 453: Line 453:
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
**[[4net]] – AbBlac<br />
**[[4net]] – AbBlac<br />
**[[5e2h]] – Blac – Mycobacterium smegmatis<br />
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
**[[5e2g]] – Blac – Burkholderia cenocepacia<br />
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />


*AmpC beta-lactamase binary complex
*AmpC beta-lactamase binary complex
Line 473: Line 473:
*Carbapenemase
*Carbapenemase


**[[3f9o]] - AhBlac B – Aeromonas hydrophila
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)
**[[6p96]] - KpBlac Oxa-48 <br />
**[[6p96]] - KpBlac Oxa-48 <br />
Line 493: Line 493:
**[[6ogo]] - EcBlac Ndm-9<br />
**[[6ogo]] - EcBlac Ndm-9<br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
**[[8ehu]] – ChBlac A – Chromobacterterium haemolyticum<br />
**[[8ehu]] – ChBlac A – ''Chromobacterterium haemolyticum''<br />


* Carbapenemase binary complexes
* Carbapenemase binary complexes
Line 513: Line 513:
**[[7t7e]] - AbBlac Oxa-23 + inhibitor<br />
**[[7t7e]] - AbBlac Oxa-23 + inhibitor<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – Vibrio cholerae<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br />
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - Klebsiella oxytoca <br />
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
**[[8ek9]] – ChBlac A + antibiotic <br />
**[[8ek9]] – ChBlac A + antibiotic <br />


Non-classified beta-lactamase
Non-classified beta-lactamase


**[[1bsg]] – Blac – Streptomyces albus
**[[1bsg]] – Blac – ''Streptomyces albus''
**[[6wgr]] -  SaBlac <br />
**[[6wgr]] -  SaBlac <br />
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant)  
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant)  
Line 534: Line 534:
**[[2jc7]], [[3g4p]] – AbBlac
**[[2jc7]], [[3g4p]] – AbBlac
**[[3byd]] – KoBlac  
**[[3byd]] – KoBlac  
**[[3i7j]] – Blac – Mycobacterium bovis
**[[3i7j]] – Blac – ''Mycobacterium bovis''
**[[3lez]] – Blac – Oceanobacter iheyensis
**[[3lez]] – Blac – ''Oceanobacter iheyensis''
**[[3p09]] – Blac – Francisella tularensis
**[[3p09]] – Blac – ''Francisella tularensis''
**[[4ewf]] – Blac – Sphaerobacter thermophilus
**[[4ewf]] – Blac – ''Sphaerobacter thermophilus''
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – Burkholderia pseudomallei<br />
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
**[[3w4q]] – BmBlac – Burkholderia multivorans<br />
**[[3w4q]] – BmBlac – ''Burkholderia multivorans''<br />
**[[7d5j]] – BmBlac (mutant)<br />
**[[7d5j]] – BmBlac (mutant)<br />
**[[5ihv]] – Blac – Burkholderia ambifaria<br />
**[[5ihv]] – Blac – ''Burkholderia ambifaria''<br />
**[[5hx9]], [[5hw3]] – Blac – Burkholderia vietnamiensis<br />
**[[5hx9]], [[5hw3]] – Blac – ''Burkholderia vietnamiensis''<br />
**[[5vpq]] – Blac – Burkholderia phymatum<br />
**[[5vpq]] – Blac – ''Burkholderia phymatum''<br />
**[[5evl]] – Blac – Chromobacterterium violaceum<br />
**[[5evl]] – Blac – ''Chromobacterterium violaceum''<br />
**[[5e43]] – Blac – Streptoporangium roseum<br />
**[[5e43]] – Blac – ''Streptoporangium roseum''<br />
**[[5e2e]] – YeBlac <br />
**[[5e2e]] – YeBlac <br />
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
Line 554: Line 554:
**[[5oe2]] – KpBlac Oxa-245 <br />
**[[5oe2]] – KpBlac Oxa-245 <br />
**[[6gth]] – KpBlac  <br />
**[[6gth]] – KpBlac  <br />
**[[7oda]] – Blac Oxa-436 – Enterobacter asburiae <br />
**[[7oda]] – Blac Oxa-436 – ''Enterobacter asburiae'' <br />
**[[3wrt]] – ChBlac – Chromohalobacter<br />
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br />
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
**[[6njk]] – Blac – Sulfitobacter<br />
**[[6njk]] – Blac – ''Sulfitobacter''<br />
**[[6n9k]], [[6x9y]], [[8jb7]] – EcBlac <br />
**[[6n9k]], [[6x9y]], [[8jb7]] – EcBlac <br />
**[[6v3q]] – PaBlac Fim-1<br />
**[[6v3q]] – PaBlac Fim-1<br />
**[[6v3u]] – ElBlac Fim-1 <br />
**[[6v3u]] – ElBlac Fim-1 <br />
**[[6n36]], [[6v4w]] – CpBlac <br />
**[[6n36]], [[6v4w]] – CpBlac <br />
**[[6mu9]] – Blac – Bacillus megaterium<br />
**[[6mu9]] – Blac – ''Bacillus megaterium''<br />
**[[6ch0]], [[6cgy]] – AaBlac – Alicyclobacillus acidoterrestris<br />
**[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br />
**[[6edm]], [[7lno]], [[7lnr]], [[7me9]] – CdBlac <br />
**[[6edm]], [[7lno]], [[7lnr]], [[7me9]] – CdBlac <br />
**[[6izc]] – VpBlac – Vibrio parahaemolyticus<br />
**[[6izc]] – VpBlac – ''Vibrio parahaemolyticus''<br />
**[[6izd]] – VpBlac (mutant)<br />
**[[6izd]] – VpBlac (mutant)<br />
**[[6wgp]] – Blac – Xanthomonas campestris<br />
**[[6wgp]] – Blac – ''Xanthomonas campestris''<br />
**[[6wgq]] – Blac – Shigella flexneri<br />
**[[6wgq]] – Blac – ''Shigella flexneri''<br />
**[[6whl]] – Blac – Legionella pneumophila<br />
**[[6whl]] – Blac – ''Legionella pneumophila''<br />
**[[6wjm]] – Blac – desulfarculus baarsii<br />
**[[6wjm]] – Blac – ''Desulfarculus baarsii''<br />


  Non-classified beta-lactamase binary complex
  Non-classified beta-lactamase binary complex

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky
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