6qa5: Difference between revisions

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'''Unreleased structure'''


The entry 6qa5 is ON HOLD
==Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in the apo form==
<StructureSection load='6qa5' size='340' side='right'caption='[[6qa5]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6qa5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QA5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.655&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qa5 OCA], [https://pdbe.org/6qa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qa5 RCSB], [https://www.ebi.ac.uk/pdbsum/6qa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qa5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASPH_HUMAN ASPH_HUMAN] Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.<ref>PMID:22586105</ref>  Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.<ref>PMID:22586105</ref>


Authors: Chowdhury, R., Pfeffer, I., Schofield, C.J.
==See Also==
 
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
Description: Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in the apo form
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Chowdhury, R]]
__TOC__
[[Category: Pfeffer, I]]
</StructureSection>
[[Category: Schofield, C.J]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chowdhury R]]
[[Category: Pfeffer I]]
[[Category: Schofield CJ]]

Latest revision as of 13:22, 23 October 2024

Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in the apo formAspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in the apo form

Structural highlights

6qa5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.655Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ASPH_HUMAN Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.[1] Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.[2]

See Also

References

  1. ↑ Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29;109(22):8682-7. doi:, 10.1073/pnas.1200667109. Epub 2012 May 14. PMID:22586105 doi:10.1073/pnas.1200667109
  2. ↑ Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29;109(22):8682-7. doi:, 10.1073/pnas.1200667109. Epub 2012 May 14. PMID:22586105 doi:10.1073/pnas.1200667109

6qa5, resolution 2.65Å

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