6neq: Difference between revisions

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-'''Unreleased structure'''
-The entry 6neq is ON HOLD
+==Structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-Class-II==
+<SX load='6neq' size='340' side='right' viewer='molstar' caption='[[6neq]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6neq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NEQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6neq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6neq OCA], [https://pdbe.org/6neq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6neq RCSB], [https://www.ebi.ac.uk/pdbsum/6neq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6neq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RT27_BOVIN RT27_BOVIN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The human mitochondrial translational initiation factor 3 (IF3mt) carries mitochondrial-specific amino acid extensions at both its N and C termini (N- and C-terminal extensions [NTE and CTE, respectively]), when compared with its eubacterial counterpart. Here we present 3.3- to 3.5-A-resolution cryoelectron microscopic structures of the mammalian 28S mitoribosomal subunit in complex with human IF3mt. Unique contacts observed between the 28S subunit and N-terminal domain of IF3mt explain its unusually high affinity for the 28S subunit, whereas the position of the mito-specific NTE suggests NTE's role in binding of initiator tRNA to the 28S subunit. The location of the C-terminal domain (CTD) clarifies its anti-association activity, whereas the orientation of the mito-specific CTE provides a mechanistic explanation for its role in destabilizing initiator tRNA in the absence of mRNA. Furthermore, our structure hints at a possible role of the CTD in recruiting leaderless mRNAs for translation initiation. Our findings highlight unique features of IF3mt in mitochondrial translation initiation.
-Authors:
+Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit.,Koripella RK, Sharma MR, Haque ME, Risteff P, Spremulli LL, Agrawal RK iScience. 2019 Feb 22;12:76-86. doi: 10.1016/j.isci.2018.12.030. Epub 2019 Jan 3. PMID:30677741<ref>PMID:30677741</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6neq" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ribosome 3D structures|Ribosome 3D structures]]
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Bos taurus]]
+[[Category: Large Structures]]
+[[Category: Agrawal R]]
+[[Category: Koripella R]]
+[[Category: Sharma M]]