6nef

Outer Membrane Cytochrome S Filament from Geobacter SulfurreducensOuter Membrane Cytochrome S Filament from Geobacter Sulfurreducens

6nef, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Structural highlights 6nef is a 1 chain structure with sequence from Geobacter sulfurreducens PCA. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OMCS_GEOSL Plays an important role in extracellular electron transfer. Can transfer electrons to insoluble Fe(3+) oxides as well as other extracellular electron acceptors, including Mn(4+) oxide and humic substances (PubMed:16332857, PubMed:20400557, PubMed:21236241). Essential for direct interspecies electron transfer (DIET) in cocultures with G. metallireducens (PubMed:23377933). Publication Abstract from PubMed Electrically conductive pili from Geobacter species, termed bacterial nanowires, are intensely studied for their biological significance and potential in the development of new materials. Using cryo-electron microscopy, we have characterized nanowires from conductive G. sulfurreducens pili preparations that are composed solely of head-to-tail stacked monomers of the six-heme C-type cytochrome OmcS. The unique fold of OmcS - closely wrapped around a continuous stack of hemes that can serve as an uninterrupted path for electron transport - generates a scaffold that supports the unbranched chain of hemes along the central axis of the filament. We present here, at 3.4 A resolution, the structure of this cytochrome-based filament and discuss its possible role in long-range biological electron transport. Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.,Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M Commun Biol. 2019 Jun 19;2:219. doi: 10.1038/s42003-019-0448-9. eCollection 2019. PMID:31240257 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.