Ras-related protein Rab: Difference between revisions
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<StructureSection load='1oix' size='340' side='right' caption='Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code [[1oix]])' scene='80/804492/Cv/1'> | <StructureSection load='1oix' size='340' side='right' caption='Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code [[1oix]])' scene='80/804492/Cv/1'> | ||
__TOC__ | |||
== Function == | == Function == | ||
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*'''Rab-1A''' is required in stress-induced autophagy<ref>PMID:36781179</ref>. | *'''Rab-1A''' is required in stress-induced autophagy<ref>PMID:36781179</ref>. | ||
*'''Rab-1B''' is required for secretion. | *'''Rab-1B''' is required for secretion. | ||
*'''Rab-2B''' | *'''Rab-2B''' regulates Golgi morphology<ref>PMID:26209634</ref>. | ||
*'''Rab-3A''' is abundant in the brain and plays a role in recruitment of synaptic vesicles for exocytosis<ref>PMID:7911226</ref>. | *'''Rab-3A''' is abundant in the brain and plays a role in recruitment of synaptic vesicles for exocytosis<ref>PMID:7911226</ref>. | ||
*'''Rab-3B''' is essential for the transportation and secretion within cells and its expression is linked to progression of various malignancies<ref>PMID:38688977</ref>. | *'''Rab-3B''' is essential for the transportation and secretion within cells and its expression is linked to progression of various malignancies<ref>PMID:38688977</ref>. | ||
*'''Rab-3C''' promotes vesicle formation and packaging<ref>PMID:36652260</ref>. | |||
*'''Rab-3D''' regulates intracellular vesicle transport during exocytosis<ref>PMID:12168804</ref>. | |||
*'''Rab-4''' regulates recycling vesicle formation<ref>PMID:12036958</ref>. | |||
*'''Rab-5A''' regulates early endosome fusion<ref>PMID:26727234</ref>. | |||
*'''Rab-6A''' regulates vesicular trafficking within the Golgi and non-Golgi compartments<ref>PMID:16536738</ref>. | |||
*'''Rab-7A''' organises the endosomal-lysosomal system<ref>PMID:31908013</ref>. | |||
*'''Rab-8A''' is the mitochondrial receptor for lipid droplets in muscle<ref>PMID:36800997</ref>. | |||
*'''Rab-9A''' regulates cargo delivery to maturing melanosomes<ref>PMID:26527546</ref>. | |||
*'''Rab-10''' involved in multiple cellular pathways<ref>PMID:29377137</ref>. | |||
*'''Rab-11A''' regulates vascular endothelial cadherin recycling and transferrin trafficking<ref>PMID:26663395</ref>. | |||
*'''Rab-11B''' regulates transferrin and integrin trafficking<ref>PMID:32541798</ref>. | |||
*'''Rab-12''' regulates degradation of transferrin receptor and of amino acid transporter<ref>PMID:21718402</ref>, .<ref>PMID:23478338</ref>. | |||
*'''Rab-18''' controls lipid droplets growth and maturation<ref>PMID:29367353</ref>. | |||
*'''Rab-21''' plays an essential role in membrane transport including endocytosis and autophagy<ref>PMID:37369821</ref>. | |||
*'''Rab-22''' controls endosomal membrane trafficking<ref>PMID:11870209</ref>. | |||
*'''Rab-23''' regulates hedgehog signaling<ref>PMID:14617350</ref>. | |||
*'''Rab-25''' confers resistance to chemotherapy<ref>PMID:32901335</ref>. | |||
*'''Rab-26''' regulates autophagic degradation<ref>PMID:33731709</ref>. | |||
*'''Rab-27A''' and '''Fab-27B''' regulate different steps of the exosome secretion pathway<ref>PMID:19966785</ref>. | |||
*'''Rab-31''' marks and controls ESCRT-independent exoxome pathway<ref>PMID:32958903</ref>. | |||
*'''Rab-32''' regulates lysosomal mTOR trafficking<ref>PMID:32295849</ref>. | |||
*'''Rab-33''' is involved in membrane trafficking and macroautophagy<ref>PMID:31408960</ref>. | |||
*'''Rab-35''' regulates the initial phase of phagosome maturation<ref>PMID:31607221</ref>. | |||
*'''Rab-43''' regulates the trafficking of adrenergic receptor and acetylcholine receptor in primary neutrons<ref>PMID:33676895</ref>. | |||
== Disease == | == Disease == | ||
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Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | ||
==3D structures of Rat-related protein Rab== | |||
[[Ras-related protein Rab 3D structures]] | [[Ras-related protein Rab 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||