Charged multivesicular body protein: Difference between revisions
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== Function == | == Function == | ||
'''Charged multivesicular body protein''' (CHMP)s are part of '''E'''ndosomal '''S'''orting '''C'''omplex '''R'''equired for '''T'''ransport ('''ESCRT''') together with the [[Vacuolar protein sorting-associated protein]]s that performs the topologically unique membrane bending and scission reaction away from the cytoplasm. This process is required for the multivesicular body (MVP) pathway, cytokinesis and HIV budding. There are five distinct ESCRT complexes (0,I,II,III,Vps4) with distinct functions<ref>PMID:22361144</ref>. CHMPs are part of the ESCRT-III complex. | '''Charged multivesicular body protein''' (CHMP)s are part of '''E'''ndosomal '''S'''orting '''C'''omplex '''R'''equired for '''T'''ransport ('''ESCRT''') together with the [[Vacuolar protein sorting-associated protein]]s that performs the topologically unique membrane bending and scission reaction away from the cytoplasm. This process is required for the multivesicular body (MVP) pathway, cytokinesis and HIV budding. There are five distinct ESCRT complexes (0,I,II,III,Vps4) with distinct functions<ref>PMID:22361144</ref>. CHMPs are part of the ESCRT-III complex. | ||
*'''CHMP1A''' and ''' | *'''CHMP1A''' and '''CHMP1B''' are required for bodies containing plastid material during autophagy into the cytoplasm <ref>PMID:25649438</ref>.<br /> | ||
*'''CHMP2B''' | *'''CHMP2B''' polymerization scaffolds membranes as part of outward membrane deformation<ref>PMID:21926173</ref>.<br /> | ||
*'''CHMP3''' sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body pathway. . | |||
*'''CHMP4B''' circular filament arrays can promote or stabilize negative membrane curvature and outward budding. | *'''CHMP4B''' circular filament arrays can promote or stabilize negative membrane curvature and outward budding. | ||
*'''CHMP5''' has possibly a regulatory role on apoptosis-associated genes. | *'''CHMP5''' has possibly a regulatory role on apoptosis-associated genes. | ||