6nb7: Difference between revisions

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-'''Unreleased structure'''
-The entry 6nb7 is ON HOLD
+==SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)==
+<SX load='6nb7' size='340' side='right' viewer='molstar' caption='[[6nb7]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nb7]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NB7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb7 OCA], [https://pdbe.org/6nb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nb7 RCSB], [https://www.ebi.ac.uk/pdbsum/6nb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb7 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the major target of neutralizing antibodies. To understand the humoral immune response elicited upon natural infections with coronaviruses, we structurally characterized the SARS-CoV and MERS-CoV S glycoproteins in complex with neutralizing antibodies isolated from human survivors. Although the two antibodies studied blocked attachment to the host cell receptor, only the anti-SARS-CoV S antibody triggered fusogenic conformational changes via receptor functional mimicry. These results provide a structural framework for understanding coronavirus neutralization by human antibodies and shed light on activation of coronavirus membrane fusion, which takes place through a receptor-driven ratcheting mechanism.
-Authors:
+Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.,Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D Cell. 2019 Jan 23. pii: S0092-8674(18)31642-8. doi: 10.1016/j.cell.2018.12.028. PMID:30712865<ref>PMID:30712865</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6nb7" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[Sandbox 3001|Sandbox 3001]]
+*[[Spike protein 3D structures|Spike protein 3D structures]]
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Severe acute respiratory syndrome-related coronavirus]]
+[[Category: Cameroni E]]
+[[Category: Corti D]]
+[[Category: Gopal R]]
+[[Category: Lanzavecchia A]]
+[[Category: Mian D]]
+[[Category: Park YJ]]
+[[Category: Quispe J]]
+[[Category: Rey FA]]
+[[Category: Snijder S]]
+[[Category: Tortorici MA]]
+[[Category: Veesler D]]
+[[Category: Walls AC]]
+[[Category: Xiong X]]
+[[Category: Zambon M]]