6nb4: Difference between revisions
No edit summary |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)== | ==MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2)== | ||
< | <SX load='6nb4' size='340' side='right' viewer='molstar' caption='[[6nb4]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6nb4]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6nb4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NB4 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb4 OCA], [https://pdbe.org/6nb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nb4 RCSB], [https://www.ebi.ac.uk/pdbsum/6nb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A140AYW5_MERS A0A140AYW5_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 6nb4" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6nb4" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cameroni | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
[[Category: Corti | [[Category: Cameroni E]] | ||
[[Category: Gopal | [[Category: Corti D]] | ||
[[Category: Lanzavecchia | [[Category: Gopal R]] | ||
[[Category: Mian | [[Category: Lanzavecchia A]] | ||
[[Category: Park | [[Category: Mian D]] | ||
[[Category: Quispe | [[Category: Park YJ]] | ||
[[Category: Rey | [[Category: Quispe J]] | ||
[[Category: Rey FA]] | |||
[[Category: Snijder | [[Category: Snijder S]] | ||
[[Category: Tortorici | [[Category: Tortorici MA]] | ||
[[Category: Veesler | [[Category: Veesler D]] | ||
[[Category: Walls | [[Category: Walls AC]] | ||
[[Category: Xiong | [[Category: Xiong X]] | ||
[[Category: Zambon | [[Category: Zambon M]] | ||