Synaptotagmin: Difference between revisions
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'''Synaptotagmin''' (SYT) are calcium-binding proteins which are conserved from nematodes to humans. Fifteen SYTs have been identified in mammals<ref>PMID:18468511</ref>. '''Synaptotagmin-1''' (SYT1) is a synaptic vesicle membrane protein and is a sensor which induces release in neurons upon binding of Ca+2 ions<ref>PMID:19412166</ref>. The C2A domain of SYT binds phospholipids in Ca+2-dependent manner<ref>PMID:9730811</ref>. The C2B domain of SYT promotes binding to other C2B domains and to accessory proteins. Ca+2 binding causes intramolecular association of domains C2A and C2B. The synaptic fusion apparatus includes the affinity between SYT and [[Syntaxin]]-1, This affinity increases by ca. 2 orders of magnitude upon binding of Ca+2<ref>PMID:7559535</ref>. | '''Synaptotagmin''' (SYT) are calcium-binding proteins which are conserved from nematodes to humans. Fifteen SYTs have been identified in mammals<ref>PMID:18468511</ref>. '''Synaptotagmin-1''' (SYT1) is a synaptic vesicle membrane protein and is a sensor which induces release in neurons upon binding of Ca+2 ions<ref>PMID:19412166</ref>. The C2A domain of SYT binds phospholipids in Ca+2-dependent manner<ref>PMID:9730811</ref>. The C2B domain of SYT promotes binding to other C2B domains and to accessory proteins. Ca+2 binding causes intramolecular association of domains C2A and C2B. The synaptic fusion apparatus includes the affinity between SYT and [[Syntaxin]]-1, This affinity increases by ca. 2 orders of magnitude upon binding of Ca+2<ref>PMID:7559535</ref>. | ||
*'''Synaptotagmin-2''' is a Ca+2 sensor for fast neurotransmitter release in | |||
*'''Synaptotagmin-3''' is a Ca+2 sensor for fast neurotransmitter release in | *'''Synaptotagmin-2''' is a Ca+2 sensor for fast neurotransmitter release in caudal brain regions<ref>PMID:17192432</ref>. | ||
*'''Synaptotagmin-3''' is a Ca+2 sensor for fast neurotransmitter release in presynapses<ref>PMID:36261524</ref>. | |||
*'''Synaptotagmin-4''' regulates membrane traffic in neurons<ref>PMID:31743468</ref>. | |||
*'''Synaptotagmin-5''' is dense-core vesicle-specific controlling Ca+2-regulated secretion<ref>PMID:12006594</ref>. | |||
*'''Synaptotagmin-7''' is a plasma membrane Ca+2 sensor in synaptic exocytosis<ref>PMID:11395007</ref>. | |||
*'''Synaptotagmin-13''' is a Ca+2-independent regulator of endocrine cell aggression and islet formation<ref>PMID:35927244</ref>. | |||
*'''Synaptotagmin-like proteins''' (SYTL) are required in a generation of a single apical surface per cell<ref>PMID:22820376</ref>. | *'''Synaptotagmin-like proteins''' (SYTL) are required in a generation of a single apical surface per cell<ref>PMID:22820376</ref>. | ||
*'''Synaptotagmin-like protein 4''' (SYTL4) is involved in intracellular membrane trafficking. | |||
== Relevance == | == Relevance == | ||