6irf: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I==
-<StructureSection load='6irf' size='340' side='right' caption='[[6irf]], [[Resolution|resolution]] 5.10&Aring;' scene=''>
+<SX load='6irf' size='340' side='right' viewer='molstar' caption='[[6irf]], [[Resolution|resolution]] 5.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6irf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6irf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IRF FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ira|6ira]], [[6irg|6irg]], [[6irh|6irh]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irf OCA], [http://pdbe.org/6irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irf RCSB], [http://www.ebi.ac.uk/pdbsum/6irf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irf ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irf OCA], [https://pdbe.org/6irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6irf RCSB], [https://www.ebi.ac.uk/pdbsum/6irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6irf ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN]] Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:[http://omim.org/entry/614254 614254]]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21376300</ref>  [[http://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2).  GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref>
-== Function ==
-[[http://www.uniprot.org/uniprot/NMDZ1_HUMAN NMDZ1_HUMAN]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). [[http://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 16: @@
 </div>
 <div class="pdbe-citations 6irf" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: Chang, S]]
+[[Category: Homo sapiens]]
-[[Category: Zhang, J]]
+[[Category: Large Structures]]
-[[Category: Zhang, X]]
+[[Category: Chang S]]
-[[Category: Zhu, S]]
+[[Category: Zhang J]]
-[[Category: Ionotropic glutamate receptor]]
+[[Category: Zhang X]]
-[[Category: Membrane protein]]
+[[Category: Zhu S]]
-[[Category: Nmda receptor]]
-[[Category: Synaptic protein]]