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<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/1'>
<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>
 
__TOC__
== Function ==
== Function ==


'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.  Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain.  Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>.  The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.   
*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain.  Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>.  The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.
*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.
*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.
*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.
*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.
*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.
*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.
*'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>.


== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==


<scene name='80/801795/Cv/3'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/4'>TextToBeDisplayed</scene>
<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).
 
</StructureSection>


==3D structures of syntaxin==
==3D structures of syntaxin==
[[Syntaxin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Syntaxin 1
**[[2xhe]] – Stx1 + Unc18 – Monosiga brevicollis<br />
*Syntaxin 1A
**[[1ez3]] – rStx1a N-terminal – rat<br />
**[[1br0]] – rStx1a N-terminal (mutant) – NMR<br />
**[[1hvv]] – rStx1a SNARE motif<br />
**[[2m8r]] – rStx1a SNARE motif - NMR<br />
**[[1jth]] – rStx1a SNARE motif + SNAP25<br />
**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
**[[5kj7]], [[5kj8]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP3 <br />
**[[2n1t]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR<br />
**[[5w5c]], [[5w5d]] – rStx1a SNARE motif + SNAP25 + VAMP2 + synaptotagmin + complexin-1<br />
**[[3c98]], [[4jeh]], [[4jeu]] – rStx1a + Unc18 <br />
**[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rStx17 SNARE motif + SNAP25 + rVAMP2 + vesicle fusion ATPase + SNAP–α – Cryo EM<br />
*Syntaxin 6
**[[1lvf]] – rStx6 N-terminal <br />
**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
*Syntaxin 7
**[[1gl2]] – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse <br />
*Syntaxin 10
**[[4dnd]] – hStx10 <br />
*Syntaxin 12
**[[2dnx]] – hStx12 N-terminal - NMR<br />
*Syntaxin 13
**[[2nps]] – rStx13 SNARE motif + VAMP4 + hStx6 SNARE motif + VTI1-RP2 <br />
*Syntaxin 17
**[[4wy4]] – rStx17 SNARE motif + SNAP29 + VAMP8<br />
*s-syntaxin
**[[1s94]] – LpStx Habc domain – Loligo pealei<br />
**[[1l4a]] – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A<br />
*Syntaxin VAM3
**[[1hs7]] – Stx N-terminal – yeast - NMR<br />
}}
== References ==
== References ==
<references/>
<references/>
 
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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