6mu1: Difference between revisions
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==Structure of full-length IP3R1 channel bound with Adenophostin A== | ==Structure of full-length IP3R1 channel bound with Adenophostin A== | ||
< | <SX load='6mu1' size='340' side='right' viewer='molstar' caption='[[6mu1]], [[Resolution|resolution]] 4.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6mu1]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6mu1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MU1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JYP: | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JYP:[(2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-[(2~{R},3~{S},4~{R},5~{S},6~{S})-6-(hydroxymethyl)-3-oxidanyl-4,5-diphosphonooxy-oxan-2-yl]oxy-oxolan-3-yl]+dihydrogen+phosphate'>JYP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mu1 OCA], [https://pdbe.org/6mu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mu1 RCSB], [https://www.ebi.ac.uk/pdbsum/6mu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mu1 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6mu1" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6mu1" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Baker | [[Category: Baker ML]] | ||
[[Category: Baker | [[Category: Baker MR]] | ||
[[Category: Fan | [[Category: Fan G]] | ||
[[Category: Ludtke | [[Category: Ludtke SJ]] | ||
[[Category: Seryshev | [[Category: Seryshev A]] | ||
[[Category: Serysheva | [[Category: Serysheva II]] | ||
[[Category: Wang | [[Category: Wang Z]] | ||