6hqa: Difference between revisions
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New page: '''Unreleased structure''' The entry 6hqa is ON HOLD until Paper Publication Authors: Kolesnikova, O., Ben-Shem, A., Luo, J., Ranish, J., Schultz, P., Papai, G. Description: Molecular ... |
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==Molecular structure of promoter-bound yeast TFIID== | |||
<SX load='6hqa' size='340' side='right' viewer='molstar' caption='[[6hqa]], [[Resolution|resolution]] 7.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hqa]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_phaffii_GS115 Komagataella phaffii GS115]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HQA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.1Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hqa OCA], [https://pdbe.org/6hqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hqa RCSB], [https://www.ebi.ac.uk/pdbsum/6hqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hqa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/C4R289_KOMPG C4R289_KOMPG] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promoter-bound yeast TFIID at a resolution better than 5 A, except for a flexible domain. We position the crystal structures of several subunits and, in combination with cross-linking studies, describe the quaternary organization of TFIID. The compact tri lobed architecture is stabilized by a topologically closed Taf5-Taf6 tetramer. We confirm the unique subunit stoichiometry prevailing in TFIID and uncover a hexameric arrangement of Tafs containing a histone fold domain in the Twin lobe. | |||
Molecular structure of promoter-bound yeast TFIID.,Kolesnikova O, Ben-Shem A, Luo J, Ranish J, Schultz P, Papai G Nat Commun. 2018 Nov 7;9(1):4666. doi: 10.1038/s41467-018-07096-y. PMID:30405110<ref>PMID:30405110</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6hqa" style="background-color:#fffaf0;"></div> | ||
[[Category: Ben-Shem | |||
[[Category: Kolesnikova | ==See Also== | ||
[[Category: Papai | *[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]] | ||
[[Category: | == References == | ||
[[Category: Schultz | <references/> | ||
__TOC__ | |||
</SX> | |||
[[Category: Komagataella phaffii GS115]] | |||
[[Category: Large Structures]] | |||
[[Category: Ben-Shem A]] | |||
[[Category: Kolesnikova O]] | |||
[[Category: Luo J]] | |||
[[Category: Papai G]] | |||
[[Category: Ranish J]] | |||
[[Category: Schultz P]] | |||
Latest revision as of 13:02, 23 October 2024
Molecular structure of promoter-bound yeast TFIIDMolecular structure of promoter-bound yeast TFIID
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