6gr8: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6gr8 is ON HOLD
+==Human AURKC INCENP complex bound to BRD-7880==
+<StructureSection load='6gr8' size='340' side='right'caption='[[6gr8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GR8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F8Z:1-[(2~{R},3~{S})-2-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2~{S})-1-oxidanylpropan-2-yl]-3,4-dihydro-2~{H}-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea'>F8Z</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr8 OCA], [https://pdbe.org/6gr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gr8 RCSB], [https://www.ebi.ac.uk/pdbsum/6gr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN] Male infertility due to large-headed multiflagellar polyploid spermatozoa. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/AURKC_HUMAN AURKC_HUMAN] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.<ref>PMID:15316025</ref> <ref>PMID:15499654</ref> <ref>PMID:15670791</ref> <ref>PMID:15938719</ref> <ref>PMID:21493633</ref> <ref>PMID:21531210</ref> <ref>PMID:27332895</ref>
-Authors: Abdul Azeez, K.R., Sorrell, F.J., von Delft, F., Bountra, C., Knapp, S., Edwards, A.M., Arrowsmith, C., Elkins, J.M.
+==See Also==
+*[[Centromere protein 3D structure|Centromere protein 3D structure]]
-Description: Human AURKC INCENP complex bound to BRD-7880
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Elkins, J.M]]
+__TOC__
-[[Category: Knapp, S]]
+</StructureSection>
-[[Category: Edwards, A.M]]
+[[Category: Homo sapiens]]
-[[Category: Abdul Azeez, K.R]]
+[[Category: Large Structures]]
-[[Category: Von Delft, F]]
+[[Category: Abdul Azeez KR]]
-[[Category: Bountra, C]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C]]
+[[Category: Bountra C]]
-[[Category: Sorrell, F.J]]
+[[Category: Edwards AM]]
+[[Category: Elkins JM]]
+[[Category: Knapp S]]
+[[Category: Sorrell FJ]]
+[[Category: Von Delft F]]