6d8h: Difference between revisions

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 ==NMR solution structure of tamapin, mutant Y31+N==
-<StructureSection load='6d8h' size='340' side='right'caption='[[6d8h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='6d8h' size='340' side='right'caption='[[6d8h]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6d8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D8H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6d8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D8H FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8h OCA], [http://pdbe.org/6d8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d8h RCSB], [http://www.ebi.ac.uk/pdbsum/6d8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8h ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8h OCA], [https://pdbe.org/6d8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d8h RCSB], [https://www.ebi.ac.uk/pdbsum/6d8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8h ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>
+[https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref>
 ==See Also==
@@ Line 15: / Line 16: @@
 __TOC__
 </StructureSection>
-[[Category: Buthus tamalus]]
 [[Category: Large Structures]]
-[[Category: Delgado, G A.Titaux]]
+[[Category: Mesobuthus tamulus]]
-[[Category: Flores, M Mayorga]]
+[[Category: Mayorga Flores M]]
-[[Category: Meneses, C M.Melchor]]
+[[Category: Melchor Meneses CM]]
-[[Category: Portilla, F del Rio]]
+[[Category: Titaux Delgado GA]]
-[[Category: Csalpha/beta]]
+[[Category: Del Rio Portilla F]]
-[[Category: Sk channel]]
-[[Category: Tamapin mutant]]
-[[Category: Toxin]]
-[[Category: Y31+n]]