6g9o: Difference between revisions

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 ==Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution==
-<StructureSection load='6g9o' size='340' side='right' caption='[[6g9o]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
+<SX load='6g9o' size='340' side='right' viewer='molstar' caption='[[6g9o]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6g9o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G9O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6g9o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G9O FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g8z|6g8z]], [[6g9l|6g9l]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lrrc8a, Lrrc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9o OCA], [https://pdbe.org/6g9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g9o RCSB], [https://www.ebi.ac.uk/pdbsum/6g9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9o ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9o OCA], [http://pdbe.org/6g9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g9o RCSB], [http://www.ebi.ac.uk/pdbsum/6g9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9o ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref>
+[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 ==See Also==
-*[[Ion channels|Ion channels]]
+*[[Ion channels 3D structures|Ion channels 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Deneka, D]]
+[[Category: Mus musculus]]
-[[Category: Dutzler, R]]
+[[Category: Deneka D]]
-[[Category: Lam, A K.M]]
+[[Category: Dutzler R]]
-[[Category: Paulino, C]]
+[[Category: Lam AKM]]
-[[Category: Sawicka, M]]
+[[Category: Paulino C]]
-[[Category: Chloride channel]]
+[[Category: Sawicka M]]
-[[Category: Leucine-rich repeat]]
-[[Category: Membrane protein]]
-[[Category: Swelling-activated]]
-[[Category: Vsoac]]