6g9o: Difference between revisions
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==Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution== | ==Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution== | ||
< | <SX load='6g9o' size='340' side='right' viewer='molstar' caption='[[6g9o]], [[Resolution|resolution]] 4.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6g9o]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6g9o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G9O FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g9o OCA], [https://pdbe.org/6g9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g9o RCSB], [https://www.ebi.ac.uk/pdbsum/6g9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g9o ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6g9o" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6g9o" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Deneka | [[Category: Mus musculus]] | ||
[[Category: Dutzler | [[Category: Deneka D]] | ||
[[Category: Lam | [[Category: Dutzler R]] | ||
[[Category: Paulino | [[Category: Lam AKM]] | ||
[[Category: Sawicka | [[Category: Paulino C]] | ||
[[Category: Sawicka M]] | |||
Latest revision as of 12:57, 23 October 2024
Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolutionStructure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution
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