6a79: Difference between revisions

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OCA

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 ==Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B==
-<StructureSection load='6a79' size='340' side='right' caption='[[6a79]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
+<StructureSection load='6a79' size='340' side='right'caption='[[6a79]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6a79]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A79 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6a79]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A79 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a79 OCA], [http://pdbe.org/6a79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a79 RCSB], [http://www.ebi.ac.uk/pdbsum/6a79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a79 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a79 OCA], [https://pdbe.org/6a79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a79 RCSB], [https://www.ebi.ac.uk/pdbsum/6a79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a79 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ROBO1_HUMAN ROBO1_HUMAN]] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.<ref>PMID:10102268</ref>
+[https://www.uniprot.org/uniprot/ROBO1_HUMAN ROBO1_HUMAN] Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.<ref>PMID:10102268</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 6a79" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Inoue, T]]
+[[Category: Homo sapiens]]
-[[Category: Kado, Y]]
+[[Category: Large Structures]]
-[[Category: Mizohata, E]]
+[[Category: Mus musculus]]
-[[Category: Nakayama, T]]
+[[Category: Inoue T]]
-[[Category: Yokota, Y]]
+[[Category: Kado Y]]
-[[Category: Angiogenesis]]
+[[Category: Mizohata E]]
-[[Category: Antibody drug]]
+[[Category: Nakayama T]]
-[[Category: Hepatocellular carcinoma antigen]]
+[[Category: Yokota Y]]
-[[Category: Immune system]]
-[[Category: Single-chain variable fragment]]