5zk3: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB==
-<StructureSection load='5zk3' size='340' side='right' caption='[[5zk3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='5zk3' size='340' side='right'caption='[[5zk3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5zk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZK3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5zk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZK3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QNB:(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL+HYDROXY(DIPHENYL)ACETATE'>QNB</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xba|5xba]], [[5xbb|5xbb]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QNB:(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL+HYDROXY(DIPHENYL)ACETATE'>QNB</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk3 OCA], [https://pdbe.org/5zk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zk3 RCSB], [https://www.ebi.ac.uk/pdbsum/5zk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk3 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk3 OCA], [http://pdbe.org/5zk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zk3 RCSB], [http://www.ebi.ac.uk/pdbsum/5zk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk3 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
+[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 </div>
 <div class="pdbe-citations 5zk3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Hirata, K]]
+[[Category: Large Structures]]
-[[Category: Horita, S]]
+[[Category: Hirata K]]
-[[Category: Iwata, S]]
+[[Category: Horita S]]
-[[Category: Kinoshita, M]]
+[[Category: Iwata S]]
-[[Category: Kobayashi, T]]
+[[Category: Kinoshita M]]
-[[Category: Kobilka, B K]]
+[[Category: Kobayashi T]]
-[[Category: Maeda, S]]
+[[Category: Kobilka BK]]
-[[Category: Murata, T]]
+[[Category: Maeda S]]
-[[Category: Suno, R]]
+[[Category: Murata T]]
-[[Category: Tawaramoto, M S]]
+[[Category: Suno R]]
-[[Category: Tsujimoto, H]]
+[[Category: Tawaramoto MS]]
-[[Category: Yamamoto, M]]
+[[Category: Tsujimoto H]]
-[[Category: Yamashita, K]]
+[[Category: Yamamoto M]]
-[[Category: Yasuda, S]]
+[[Category: Yamashita K]]
-[[Category: Gpcr crystallography]]
+[[Category: Yasuda S]]
-[[Category: Membrane protein-inhibitor complex]]
-[[Category: Rationally thermostabilized mutant]]