6fnv: Difference between revisions

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 ==Solution structure of mule deer prion protein with polymorphism S138==
-<StructureSection load='6fnv' size='340' side='right'caption='[[6fnv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='6fnv' size='340' side='right'caption='[[6fnv]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6fnv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6fnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Odocoileus_hemionus Odocoileus hemionus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FNV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnv OCA], [http://pdbe.org/6fnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fnv RCSB], [http://www.ebi.ac.uk/pdbsum/6fnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnv ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fnv OCA], [https://pdbe.org/6fnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fnv RCSB], [https://www.ebi.ac.uk/pdbsum/6fnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fnv ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PRIO_ODOHE PRIO_ODOHE] Found in high quantity in the brain of animals infected with the degenerative neurological disease known as chronic wasting disease (CWD).
+== Function ==
+[https://www.uniprot.org/uniprot/PRIO_ODOHE PRIO_ODOHE] Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).[UniProtKB:P04156][UniProtKB:P04925]
+==See Also==
+*[[Prion 3D structures|Prion 3D structures]]
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Ilc, G]]
+[[Category: Odocoileus hemionus]]
-[[Category: Plavec, J]]
+[[Category: Ilc G]]
-[[Category: Slapsak, U]]
+[[Category: Plavec J]]
-[[Category: Membrane protein]]
+[[Category: Slapsak U]]
-[[Category: Prion protein]]