6bsl: Difference between revisions

<StructureSection load='6bsl' size='340' side='right'caption='[[6bsl]], [[Resolution|resolution]] 1.45&Aring;' scene=''>

<table><tr><td colspan='2'>[[6bsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BSL FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EVV:(2~{S})-2-[[2-ethoxy-4-[5-[[[(2~{R})-2-[(1~{R})-1-[methanoyl(oxidanyl)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]phenyl]carbonylamino]butanedioic+acid'>EVV</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsl OCA], [https://pdbe.org/6bsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bsl RCSB], [https://www.ebi.ac.uk/pdbsum/6bsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsl ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BMP1_HUMAN BMP1_HUMAN] Defects in BMP1 are the cause of osteogenesis imperfecta 13 (OI13) [MIM:[https://omim.org/entry/614856 614856]. An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs.<ref>PMID:22482805</ref> <ref>PMID:22052668</ref>  

[https://www.uniprot.org/uniprot/BMP1_HUMAN BMP1_HUMAN] Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gampe R]]

[[Category: Shewchuk L]]