6exl: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK206) - folded HTH motif==
-<StructureSection load='6exl' size='340' side='right' caption='[[6exl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='6exl' size='340' side='right'caption='[[6exl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6exl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EXL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6exl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EXL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2Q:[(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium'>C2Q</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2Q:[(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium'>C2Q</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f1r|5f1r]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6exl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exl OCA], [https://pdbe.org/6exl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6exl RCSB], [https://www.ebi.ac.uk/pdbsum/6exl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6exl ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prfA, AJN46_04535, BWI22_01025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 "Bacterium monocytogenes hominis" Nyfeldt 1932])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6exl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exl OCA], [http://pdbe.org/6exl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6exl RCSB], [http://www.ebi.ac.uk/pdbsum/6exl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6exl ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRFA_LISMO PRFA_LISMO] Positively regulates expression of listeriolysin, of 1-phosphadidylinositol phosphodiesterase (PI-PLC) and other virulence factors.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 6exl" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bacterium monocytogenes hominis nyfeldt 1932]]
+[[Category: Large Structures]]
-[[Category: Almqvist, F]]
+[[Category: Listeria monocytogenes]]
-[[Category: Begum, A]]
+[[Category: Almqvist F]]
-[[Category: Grundstrom, C]]
+[[Category: Begum A]]
-[[Category: Hall, M]]
+[[Category: Grundstrom C]]
-[[Category: Johansson, J]]
+[[Category: Hall M]]
-[[Category: Kulen, M]]
+[[Category: Johansson J]]
-[[Category: Lindgren, M]]
+[[Category: Kulen M]]
-[[Category: Sauer, U H]]
+[[Category: Lindgren M]]
-[[Category: Sauer-Eriksson, A E]]
+[[Category: Sauer UH]]
-[[Category: 2-pyridone]]
+[[Category: Sauer-Eriksson AE]]
-[[Category: Dna binding]]
-[[Category: Dna binding protein]]
-[[Category: Drug design]]
-[[Category: Listeria monocytogene]]
-[[Category: Transcription regulator]]