6ej1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6ej1 is ON HOLD
+==Crystal structure of KDM5B in complex with KDOPZ48a.==
+<StructureSection load='6ej1' size='340' side='right'caption='[[6ej1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ej1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EJ1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7Q:5-[1-[1-(2-chloranylethanoyl)piperidin-4-yl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile'>B7Q</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ej1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ej1 OCA], [https://pdbe.org/6ej1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ej1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ej1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ej1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
-Authors: Srikannathasan, v., Szykowska, A., Newman, J.A., Kupinska, K., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Huber, K., von Delft, F.
+==See Also==
+*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
-Description: Crystal structure of KDM5B in complex with KDOPZ48a.
+*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Burgess-Brown, N.A]]
+<references/>
-[[Category: Bountra, C]]
+__TOC__
-[[Category: Kupinska, K]]
+</StructureSection>
-[[Category: Huber, K]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Large Structures]]
-[[Category: Oppermann, U]]
+[[Category: Arrowsmith CH]]
-[[Category: Szykowska, A]]
+[[Category: Bountra C]]
-[[Category: Von Delft, F]]
+[[Category: Burgess-Brown NA]]
-[[Category: Newman, J.A]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Huber K]]
-[[Category: Strain-Damerell, C]]
+[[Category: Kupinska K]]
-[[Category: Srikannathasan, V]]
+[[Category: Newman JA]]
+[[Category: Oppermann U]]
+[[Category: Ruda GF]]
+[[Category: Srikannathasan V]]
+[[Category: Strain-Damerell C]]
+[[Category: Szykowska A]]
+[[Category: Vazquez-Rodriguez SA]]
+[[Category: Wright M]]
+[[Category: Von Delft F]]