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==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
<StructureSection load='6atm' size='340' side='right' caption='[[6atm]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='6atm' size='340' side='right'caption='[[6atm]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6atm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6atm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_israelis Buthus israelis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ATM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atm OCA], [http://pdbe.org/6atm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atm RCSB], [http://www.ebi.ac.uk/pdbsum/6atm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atm ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6atm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atm OCA], [https://pdbe.org/6atm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6atm RCSB], [https://www.ebi.ac.uk/pdbsum/6atm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6atm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAX3A_BUTIS KAX3A_BUTIS] Inhibits insect potassium channel. Is at least a 100-fold more potent against the Drosophila Shaker channel than towards its mammalian homologs Kv1.1/KCNA1 and Kv1.3/KCNA3.<ref>PMID:17490656</ref> <ref>PMID:29483648</ref>
==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gewe, M M]]
[[Category: Buthus israelis]]
[[Category: Rupert, P]]
[[Category: Large Structures]]
[[Category: Strong, R K]]
[[Category: Gewe MM]]
[[Category: Cystine knot]]
[[Category: Rupert P]]
[[Category: Knottin]]
[[Category: Strong RK]]
[[Category: Toxin]]

Latest revision as of 15:26, 6 November 2024

Exploring Cystine Dense Peptide Space to Open a Unique Molecular ToolboxExploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

Structural highlights

6atm is a 1 chain structure with sequence from Buthus israelis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.09Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAX3A_BUTIS Inhibits insect potassium channel. Is at least a 100-fold more potent against the Drosophila Shaker channel than towards its mammalian homologs Kv1.1/KCNA1 and Kv1.3/KCNA3.[1] [2]

See Also

References

  1. ↑ Kozminsky-Atias A, Somech E, Zilberberg N. Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels. FEBS Lett. 2007 May 29;581(13):2478-84. PMID:17490656 doi:10.1016/j.febslet.2007.04.065
  2. ↑ Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub, 2018 Feb 26. PMID:29483648 doi:http://dx.doi.org/10.1038/s41594-018-0033-9

6atm, resolution 2.09Å

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