5opt: Difference between revisions

Latest revision as of 07:33, 21 November 2024

Structure of KSRP in context of Trypanosoma cruzi 40SStructure of KSRP in context of Trypanosoma cruzi 40S

5opt, resolution 4.00Å

Structural highlights

5opt is a 10 chain structure with sequence from Trypanosoma cruzi strain CL Brener. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4Å
Experimental data:	Check
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q4CXR4_TRYCC

Publication Abstract from PubMed

Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized. Here, we present the near-atomic cryoelectron microscopy structure of a novel bona fide kinetoplastid-specific ribosomal (r-) protein (KSRP) bound to the ribosome. KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. KSRP also interacts with the r-protein eS6 at a region that is only conserved in kinetoplastids. The kinetoplastid-specific ribosomal environment of KSRP provides a promising target for the design of safer anti-kinetoplastidian drugs.

The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.,Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485 doi:http://dx.doi.org/10.1016/j.str.2017.09.014

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OCA

[1] Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485 doi:http://dx.doi.org/10.1016/j.str.2017.09.014

[1]

@@ Line 1: / Line 1: @@
 ==Structure of KSRP in context of Trypanosoma cruzi 40S==
-<StructureSection load='5opt' size='340' side='right' caption='[[5opt]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+<SX load='5opt' size='340' side='right' viewer='molstar' caption='[[5opt]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5opt]] is a 35 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OPT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5opt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OPT FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opt OCA], [http://pdbe.org/5opt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5opt RCSB], [http://www.ebi.ac.uk/pdbsum/5opt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5opt ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opt OCA], [https://pdbe.org/5opt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5opt RCSB], [https://www.ebi.ac.uk/pdbsum/5opt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5opt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/Q4CQ63_TRYCC Q4CQ63_TRYCC]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.[HAMAP-Rule:MF_03015]
+[https://www.uniprot.org/uniprot/Q4CXR4_TRYCC Q4CXR4_TRYCC]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 18: @@
 </div>
 <div class="pdbe-citations 5opt" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ribosome 3D structures|Ribosome 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: Bochler, A]]
+[[Category: Large Structures]]
-[[Category: Chicher, J]]
+[[Category: Trypanosoma cruzi strain CL Brener]]
-[[Category: Hashem, Y]]
+[[Category: Bochler A]]
-[[Category: Mancera-Martinez, E]]
+[[Category: Brito Querido J]]
-[[Category: Querido, J Brito]]
+[[Category: Chicher J]]
-[[Category: Simonetti, A]]
+[[Category: Hashem Y]]
-[[Category: Vicens, Q]]
+[[Category: Mancera-Martinez E]]
-[[Category: Cryo-em]]
+[[Category: Simonetti A]]
-[[Category: Kinetoplastid]]
+[[Category: Vicens Q]]
-[[Category: Ksrp]]
-[[Category: Ribosome]]

5opt: Difference between revisions

Latest revision as of 07:33, 21 November 2024

Structure of KSRP in context of Trypanosoma cruzi 40SStructure of KSRP in context of Trypanosoma cruzi 40S

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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Navigation menu

5opt: Difference between revisions

Latest revision as of 07:33, 21 November 2024

Structure of KSRP in context of Trypanosoma cruzi 40SStructure of KSRP in context of Trypanosoma cruzi 40S

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

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