Nitrophorin: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Heme-containing nitrophorin 7 complex with NO and glycerol (PDB code [[4xme]])' scene='77/776390/Cv/1'> | ||
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'''Nitrophorins''' (NP) are NO transport heme-containing proteins from the saliva of blood-feeding insects which act as vasodilators and anti-platelet agents<ref>PMID:9782054</ref>. The NO is bound to the ferric form of NP with Kds in the micromolar or nanomolar range. Thus upon injection of the saliva into the tissue of the victim, the NO ca dissociate to cause vasodilation and inhibition of platelet aggregation<ref>PMID:15598503</ref>. | '''Nitrophorins''' (NP) are NO transport heme-containing proteins from the saliva of blood-feeding insects which act as vasodilators and anti-platelet agents<ref>PMID:9782054</ref>. The NO is bound to the ferric form of NP with Kds in the micromolar or nanomolar range. Thus upon injection of the saliva into the tissue of the victim, the NO ca dissociate to cause vasodilation and inhibition of platelet aggregation<ref>PMID:15598503</ref>. | ||
*'''Nitrophorin 2''' is an inhibitor of the intrinsic factor X-activating complex<ref>PMID:9692958</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The NPs structures contain a large component of β-sheet structure which is unusual for heme-containing proteins<ref>PMID:15598503</ref>. | The <scene name='77/776390/Cv/2'>NPs structures contain a large component of β-sheet structure</scene> which is unusual for heme-containing proteins<ref>PMID:15598503</ref>. {{Template:ColorKey_Helix}}, {{Template:ColorKey_Strand}}, | ||
{{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}. The <scene name='77/776390/Cv/3'>NO molecule is bound to the ferric heme opposite the His residue interacting with it</scene><ref>PMID:26167269</ref>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of | == 3D Structures of nitrophorin == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[4xmc]], [[4xmd]] – RpNP7<br /> | **[[4xmc]], [[4xmd]] – RpNP7<br /> | ||
**[[5m6j]] – RpNP7 (mutant)<br /> | |||
**[[4xme]] – RpNP7 + NO <br /> | **[[4xme]] – RpNP7 + NO <br /> | ||
**[[4xmf]] – RpNP7 + histamine <br /> | **[[4xmf]] – RpNP7 + histamine <br /> | ||
**[[4xmg]] – RpNP7 + imidazole <br /> | **[[4xmg]] – RpNP7 + imidazole <br /> | ||
**[[5m6k]] – RpNP7 (mutant) + imidazole<br /> | |||
**[[4xmh]] – RpNP7 + tripeptide <br /> | **[[4xmh]] – RpNP7 + tripeptide <br /> | ||