5yid: Difference between revisions

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 ==Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum==
-<StructureSection load='5yid' size='340' side='right' caption='[[5yid]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='5yid' size='340' side='right'caption='[[5yid]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5yid]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YID FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5yid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YID FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=K95:(4R)-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-3-[(2S,3S)-2-HYDROXY-3-{[S-METHYL-N-(PHENYLACETYL)-L-CYSTEINYL]AMINO}-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>K95</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=K95:(4R)-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-3-[(2S,3S)-2-HYDROXY-3-{[S-METHYL-N-(PHENYLACETYL)-L-CYSTEINYL]AMINO}-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>K95</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yid OCA], [http://pdbe.org/5yid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yid RCSB], [http://www.ebi.ac.uk/pdbsum/5yid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yid ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yid OCA], [https://pdbe.org/5yid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yid RCSB], [https://www.ebi.ac.uk/pdbsum/5yid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yid ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLM2_PLAF7 PLM2_PLAF7] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:29943906). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:P46925]<ref>PMID:29943906</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 </div>
 <div class="pdbe-citations 5yid" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Plasmepsin|Plasmepsin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Plasmepsin II]]
+[[Category: Large Structures]]
-[[Category: Bhaumik, P]]
+[[Category: Plasmodium falciparum 3D7]]
-[[Category: Mishra, V]]
+[[Category: Bhaumik P]]
-[[Category: Rathore, I]]
+[[Category: Mishra V]]
-[[Category: Aspartic protease]]
+[[Category: Rathore I]]
-[[Category: Drug development]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]
-[[Category: Kni-10395]]
-[[Category: Plasmepsin]]
-[[Category: Plasmepsin ii]]
-[[Category: Plasmodium falciparum]]