Liver X receptor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 5: | Line 5: | ||
'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | '''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | ||
*'''Liver X receptor alpha''' has a role in regulating innate immunity at the genomic level. | |||
*'''Liver X receptor beta''' is an important transcription factor promoting the survival of single-positive thymocytes<ref>PMID:32963358</ref>. | |||
See also [[Intracellular receptors]] | See also [[Intracellular receptors]] | ||